inclusion criteria: - recipient: severe covid -19 infections defined as who interim guidance and the guideline of diagnosis and treatment of covid-19 of national health commission of china (version 5.0) with confirmation by real-time rt-pcr assay with severe disease i.e. meeting any 2 of the following criteria- respiratory distress, rr ≥30 beats/min oxygen saturation level less than 93% in resting state partial pressure of oxygen (pao2)/oxygen concentration (fio2) ≤ 300 mmhg. lung infiltrates > 50% within 24 to 48 hours very sick (on ventilator) and patients with co-morbidities such as patients with known co-morbid diseases (copd, cad, cld, ckd, cardiopulmonary disease-structural or valvular heart disease) patient presenting with multi organ failure or requiring mechanical ventilation. donor: known case of recovered covid-19 infection, and complete resolution of symptoms at least 28 days prior to donation or complete resolution of symptoms at least 14 days prior to donation and negative results for covid-19 either from one or more nasopharyngeal swab specimens or by a molecular diagnostic test from the blood, and negative rt-pcr for covid-19 on two sequential paired nasopharyngeal and throat specimens > 24 hrs apart (who-cdc guideline). donor plasma after 2 negative tests and 2 weeks of remaining asymptomatic, without antibody titre & presence of igg/igm antibodies to covid-19 by serological as per manufacturers instructions. donors negative for these will be deferred). fulfill all criteria of donor eligibility for donor plasmapheresis under the drugs & cosmetics act and rules 1945, amended 11.03.2020.

inclusion criteria: - recipient: severe covid -19 infections defined as who interim guidance and the guideline of diagnosis and treatment of covid-19 of national health commission of china (version 5.0) with confirmation by real-time rt-pcr assay with severe disease i.e. meeting any 2 of the following criteria- respiratory distress, rr ≥30 beats/min oxygen saturation level less than 93% in resting state partial pressure of oxygen (pao2)/oxygen concentration (fio2) ≤ 300 mmhg. lung infiltrates > 50% within 24 to 48 hours very sick (on ventilator) and patients with co-morbidities such as patients with known co-morbid diseases (copd, cad, cld, ckd, cardiopulmonary disease-structural or valvular heart disease) patient presenting with multi organ failure or requiring mechanical ventilation. donor: known case of recovered covid-19 infection, and complete resolution of symptoms at least 28 days prior to donation or complete resolution of symptoms at least 14 days prior to donation and negative results for covid-19 either from one or more nasopharyngeal swab specimens or by a molecular diagnostic test from the blood, and negative rt-pcr for covid-19 on two sequential paired nasopharyngeal and throat specimens > 24 hrs apart (who-cdc guideline). donor plasma after 2 negative tests and 2 weeks of remaining asymptomatic, without antibody titre & presence of igg/igm antibodies to covid-19 by serological as per manufacturers instructions. donors negative for these will be deferred). fulfill all criteria of donor eligibility for donor plasmapheresis under the drugs & cosmetics act and rules 1945, amended 11.03.2020.

inclusion criteria: - recipient: severe covid -19 infections defined as who interim guidance and the guideline of diagnosis and treatment of covid-19 of national health commission of china (version 5.0) with confirmation by real-time rt-pcr assay with severe disease i.e. meeting any 2 of the following criteria- 1. respiratory distress, rr ≥30 beats/min 2. oxygen saturation level less than 93% in resting state 3. partial pressure of oxygen (pao2)/oxygen concentration (fio2) ≤ 300 mmhg. 4. lung infiltrates > 50% within 24 to 48 hours 5. very sick (on ventilator) and patients with co-morbidities such as patients with known co-morbid diseases (copd, cad, cld, ckd, cardiopulmonary disease-structural or valvular heart disease) 6. patient presenting with multi organ failure or requiring mechanical ventilation. donor: - known case of recovered covid-19 infection, and - complete resolution of symptoms at least 28 days prior to donation or complete resolution of symptoms at least 14 days prior to donation and negative results for covid-19 either from one or more nasopharyngeal swab specimens or by a molecular diagnostic test from the blood, and negative rt-pcr for covid-19 on two sequential paired nasopharyngeal and throat specimens > 24 hrs apart (who-cdc guideline). - donor plasma after 2 negative tests and 2 weeks of remaining asymptomatic, without antibody titre & presence of igg/igm antibodies to covid-19 by serological as per manufacturers instructions. donors negative for these will be deferred). - fulfill all criteria of donor eligibility for donor plasmapheresis under the drugs & cosmetics act and rules 1945, amended 11.03.2020.

inclusion criteria: - recipient: severe covid -19 infections defined as who interim guidance and the guideline of diagnosis and treatment of covid-19 of national health commission of china (version 5.0) with confirmation by real-time rt-pcr assay with severe disease i.e. meeting any 2 of the following criteria- 1. respiratory distress, rr ≥30 beats/min 2. oxygen saturation level less than 93% in resting state 3. partial pressure of oxygen (pao2)/oxygen concentration (fio2) ≤ 300 mmhg. 4. lung infiltrates > 50% within 24 to 48 hours 5. very sick (on ventilator) and patients with co-morbidities such as patients with known co-morbid diseases (copd, cad, cld, ckd, cardiopulmonary disease-structural or valvular heart disease) 6. patient presenting with multi organ failure or requiring mechanical ventilation. donor: - known case of recovered covid-19 infection, and - complete resolution of symptoms at least 28 days prior to donation or complete resolution of symptoms at least 14 days prior to donation and negative results for covid-19 either from one or more nasopharyngeal swab specimens or by a molecular diagnostic test from the blood, and negative rt-pcr for covid-19 on two sequential paired nasopharyngeal and throat specimens > 24 hrs apart (who-cdc guideline). - donor plasma after 2 negative tests and 2 weeks of remaining asymptomatic, without antibody titre & presence of igg/igm antibodies to covid-19 by serological as per manufacturers instructions. donors negative for these will be deferred). - fulfill all criteria of donor eligibility for donor plasmapheresis under the drugs & cosmetics act and rules 1945, amended 11.03.2020.