- recipient - patients with age less than 18 years. - pregnancy - individual with hiv and hepatitis - morbid obesity bmi>35 kg/m2 - extremely moribund patients with an expected life expectancy of less than 24 hours. - failure to give informed consent from the patient or family members. - hemodynamic instability requiring vasopressors. - previous allergic history to plasma. donor: - donors age < 18 & ≥60 years old - do not fulfil all criteria of donor eligibility for donor plasmapheresis under the drugs & cosmetics act and rules 1945, amended 11.03.2020. - females who have been pregnant and previously transfused donors (to prevent trali). - donors who have taken steroids during treatment for covid-19.

- recipient - patients with age less than 18 years. - pregnancy - individual with hiv and hepatitis - morbid obesity bmi>35 kg/m2 - extremely moribund patients with an expected life expectancy of less than 24 hours. - failure to give informed consent from the patient or family members. - hemodynamic instability requiring vasopressors. - previous allergic history to plasma. donor: - donors age < 18 & ≥60 years old - do not fulfil all criteria of donor eligibility for donor plasmapheresis under the drugs & cosmetics act and rules 1945, amended 11.03.2020. - females who have been pregnant and previously transfused donors (to prevent trali). - donors who have taken steroids during treatment for covid-19.