- absence of signed informed consent - spo2 < 90 % ambient air or < 94 % with oxygenotherapy > or = 3l/min - need of oxygenotherapy > 6 l/min or mechanical ventilation - need of hospitalization in icu - alat/asat > 5 lsn - renal failure (egfr < 40 ml/min ) or dialysis - pregnancy or breastfeeding - retinopathy - known deficit in g6pd - cardiac rythm / lengthening qt disorders - qt space lengthening on ecg with qtc > 450 ms - concomitant treatment :citalopram, escitalopram, hydroxyzine, domperidone, pipéraquine, anti-arhythmic class ia & iii, antidepressive drugs,..

- absence of signed informed consent - spo2 < 90 % ambient air or < 94 % with oxygenotherapy > or = 3l/min - need of oxygenotherapy > 6 l/min or mechanical ventilation - need of hospitalization in icu - alat/asat > 5 lsn - renal failure (egfr < 40 ml/min ) or dialysis - pregnancy or breastfeeding - retinopathy - known deficit in g6pd - cardiac rythm / lengthening qt disorders - qt space lengthening on ecg with qtc > 450 ms - concomitant treatment :citalopram, escitalopram, hydroxyzine, domperidone, pipéraquine, anti-arhythmic class ia & iii, antidepressive drugs,..