inclusion criteria: 1) hospitalised symptomatic covid-19 patients 2( presence of clinical and radiological signs of progressive disease, and laboratory evidence indicative of risk for cytokine storm complications. all patients participating in this clinical trial must meet the following inclusion criteria: hospitalised symptomatic covid-19 patients presence of clinical and radiological signs of progressive disease, and laboratory evidence indicative of risk for cytokine storm complications: clinical: dyspnoea or rr>20 breaths/min and o2 sat <93% on ra or increasing need for o2 supplementation to maintain o2 sat >95% on ra with radiological: cxr or ct indicative of pneumonia or worsening findings over time and laboratory: crp levels >60 or an increase of crp >20 over 12 hours with an increasing ferritin level or declining lymphocyte counts age > 18 years and able to give consent

inclusion criteria: 1) hospitalised symptomatic covid-19 patients 2( presence of clinical and radiological signs of progressive disease, and laboratory evidence indicative of risk for cytokine storm complications. all patients participating in this clinical trial must meet the following inclusion criteria: hospitalised symptomatic covid-19 patients presence of clinical and radiological signs of progressive disease, and laboratory evidence indicative of risk for cytokine storm complications: clinical: dyspnoea or rr>20 breaths/min and o2 sat <93% on ra or increasing need for o2 supplementation to maintain o2 sat >95% on ra with radiological: cxr or ct indicative of pneumonia or worsening findings over time and laboratory: crp levels >60 or an increase of crp >20 over 12 hours with an increasing ferritin level or declining lymphocyte counts age > 18 years and able to give consent

inclusion criteria: 1) hospitalised symptomatic covid-19 patients 2( presence of clinical and radiological signs of progressive disease, and laboratory evidence indicative of risk for cytokine storm complications. all patients participating in this clinical trial must meet the following inclusion criteria: 1. hospitalised symptomatic covid-19 patients 2. presence of clinical and radiological signs of progressive disease, and laboratory evidence indicative of risk for cytokine storm complications: clinical: dyspnoea or rr>20 breaths/min and o2 sat <93% on ra or increasing need for o2 supplementation to maintain o2 sat >95% on ra with radiological: cxr or ct indicative of pneumonia or worsening findings over time and laboratory: crp levels >60 or an increase of crp >20 over 12 hours with an increasing ferritin level or declining lymphocyte counts 3. age > 18 years and able to give consent

inclusion criteria: 1) hospitalised symptomatic covid-19 patients 2( presence of clinical and radiological signs of progressive disease, and laboratory evidence indicative of risk for cytokine storm complications. all patients participating in this clinical trial must meet the following inclusion criteria: 1. hospitalised symptomatic covid-19 patients 2. presence of clinical and radiological signs of progressive disease, and laboratory evidence indicative of risk for cytokine storm complications: clinical: dyspnoea or rr>20 breaths/min and o2 sat <93% on ra or increasing need for o2 supplementation to maintain o2 sat >95% on ra with radiological: cxr or ct indicative of pneumonia or worsening findings over time and laboratory: crp levels >60 or an increase of crp >20 over 12 hours with an increasing ferritin level or declining lymphocyte counts 3. age > 18 years and able to give consent