- hypersensitivity to chloroquine or hydroxychloroquine; - women during pregnancy; - severe heart, lung, kidney, brain, blood diseases or other important systemic diseases; - participants with retinal disease, hearing loss; - participants with severe neurological and mental illness; - subjects were considered to be unable to complete the study, or not suitable for the study by researchers. exit criteria: - subjects asked to withdraw the study - subject will benefit if withdraw according to researchers' suggestions

- hypersensitivity to chloroquine or hydroxychloroquine; - women during pregnancy; - severe heart, lung, kidney, brain, blood diseases or other important systemic diseases; - participants with retinal disease, hearing loss; - participants with severe neurological and mental illness; - subjects were considered to be unable to complete the study, or not suitable for the study by researchers. exit criteria: - subjects asked to withdraw the study - subject will benefit if withdraw according to researchers' suggestions