inclusion criteria: - adult ≥ 18 years of age at the time of inclusion in the study; - recently hospitalized patients in whom sars cov-2 infection has been laboratory confirmed by rt-pcr or other commercial or public health test on any sample. - severity of 3-4-5 according to the who 7-point ordinal scale (3: hospitalized, no oxygen therapy; 4: hospitalized, oxygen by mask or nasal prongs; 5:non-invasive ventilation or high-flow oxygen); - subject (or authorized legal representative) who can provide oral or written informed consent before beginning any study procedure; - understand and agree to abide by the study procedures.

inclusion criteria: - adult ≥ 18 years of age at the time of inclusion in the study; - recently hospitalized patients in whom sars cov-2 infection has been laboratory confirmed by rt-pcr or other commercial or public health test on any sample. - severity of 3-4-5 according to the who 7-point ordinal scale (3: hospitalized, no oxygen therapy; 4: hospitalized, oxygen by mask or nasal prongs; 5:non-invasive ventilation or high-flow oxygen); - subject (or authorized legal representative) who can provide oral or written informed consent before beginning any study procedure; - understand and agree to abide by the study procedures.

inclusion criteria: - adult ≥ 18 years of age at the time of inclusion in the study; - has laboratory-confirmed sars-cov-2 infection as determined by rt-pcr, or other commercial or public health assay in any specimen as diagnosed within 72 hours prior to randomization; - severity of 3-4-5 according to the who 7-point ordinal scale (3: hospitalized, no oxygen therapy; 4: hospitalized, oxygen by mask or nasal prongs; 5:non-invasive ventilation or high-flow oxygen); - subject (or authorized legal representative) who can provide oral or written informed consent before beginning any study procedure; - understand and agree to abide by the study procedures.

inclusion criteria: - adult ≥ 18 years of age at the time of inclusion in the study; - has laboratory-confirmed sars-cov-2 infection as determined by rt-pcr, or other commercial or public health assay in any specimen as diagnosed within 72 hours prior to randomization; - severity of 3-4-5 according to the who 7-point ordinal scale (3: hospitalized, no oxygen therapy; 4: hospitalized, oxygen by mask or nasal prongs; 5:non-invasive ventilation or high-flow oxygen); - subject (or authorized legal representative) who can provide oral or written informed consent before beginning any study procedure; - understand and agree to abide by the study procedures.