inclusion criteria: male or female, ≥ 18 years old diagnosed with covid-19, as evaluated by laboratory diagnostic test or diagnosis based on radiological clinical findings baseline severity categorization of severe or critical covid-19 infection per fda guidance for developing drugs and biological products for covid-19 (february 2021) severe covid-19 symptoms suggestive of severe systemic illness with covid-19, which include shortness of breath or respiratory distress clinical signs indicative of severe systemic illness with covid-19, such as respiratory rate ≥ 30 per minute, heart rate ≥ 125 per minute, spo2 ≤ 93% on room air at sea level (spo2 ≤ 90% at altitude) or pao2/fio2 < 300 critical covid-19 oxygen delivered by high-flow nasal cannula (heated, humidified, oxygen delivered via reinforced cannula at flow rates >20 l/min with fraction oxygen ≥ 0.5) or non-invasive mechanical or endotracheal mechanical ventilation informed consent obtained from the patient or the patient's legal representative

inclusion criteria: male or female, ≥ 18 years old diagnosed with covid-19, as evaluated by laboratory diagnostic test or diagnosis based on radiological clinical findings baseline severity categorization of severe or critical covid-19 infection per fda guidance for developing drugs and biological products for covid-19 (february 2021) severe covid-19 symptoms suggestive of severe systemic illness with covid-19, which include shortness of breath or respiratory distress clinical signs indicative of severe systemic illness with covid-19, such as respiratory rate ≥ 30 per minute, heart rate ≥ 125 per minute, spo2 ≤ 93% on room air at sea level (spo2 ≤ 90% at altitude) or pao2/fio2 < 300 critical covid-19 oxygen delivered by high-flow nasal cannula (heated, humidified, oxygen delivered via reinforced cannula at flow rates >20 l/min with fraction oxygen ≥ 0.5) or non-invasive mechanical or endotracheal mechanical ventilation informed consent obtained from the patient or the patient's legal representative

inclusion criteria: 1. male or female, ≥ 18 years old 2. diagnosed with covid-19, as evaluated by laboratory diagnostic test or diagnosis based on radiological clinical findings 3. baseline severity categorization of severe or critical covid-19 infection per fda guidance for developing drugs and biological products for covid-19 (february 2021) 1. severe covid-19 - symptoms suggestive of severe systemic illness with covid-19, which include shortness of breath or respiratory distress - clinical signs indicative of severe systemic illness with covid-19, such as respiratory rate ≥ 30 per minute, heart rate ≥ 125 per minute, spo2 ≤ 93% on room air at sea level (spo2 ≤ 90% at altitude) or pao2/fio2 < 300 2. critical covid-19 - oxygen delivered by high-flow nasal cannula (heated, humidified, oxygen delivered via reinforced cannula at flow rates >20 l/min with fraction oxygen ≥ 0.5) or - non-invasive mechanical or endotracheal mechanical ventilation 4. informed consent obtained from the patient or the patient's legal representative

inclusion criteria: 1. male or female, ≥ 18 years old 2. diagnosed with covid-19, as evaluated by laboratory diagnostic test or diagnosis based on radiological clinical findings 3. baseline severity categorization of severe or critical covid-19 infection per fda guidance for developing drugs and biological products for covid-19 (february 2021) 1. severe covid-19 - symptoms suggestive of severe systemic illness with covid-19, which include shortness of breath or respiratory distress - clinical signs indicative of severe systemic illness with covid-19, such as respiratory rate ≥ 30 per minute, heart rate ≥ 125 per minute, spo2 ≤ 93% on room air at sea level (spo2 ≤ 90% at altitude) or pao2/fio2 < 300 2. critical covid-19 - oxygen delivered by high-flow nasal cannula (heated, humidified, oxygen delivered via reinforced cannula at flow rates >20 l/min with fraction oxygen ≥ 0.5) or - non-invasive mechanical or endotracheal mechanical ventilation 4. informed consent obtained from the patient or the patient's legal representative