illness severe enough to require hospitalization or already meeting study's primary endpoint for clinical worsening. unstable medical comorbidities including, but not limited to: severe underlying lung disease (copd on home oxygen, interstitial lung disease, pulmonary hypertension), decompensated cirrhosis, congestive heart failure (stage 3 or 4 per patient report and/or medical records). immunocompromised (solid organ transplant, bmt, aids, on biologics and/or high dose steroids (>20mg prednisone per day) unable to provide informed consent (eg moderate-severe dementia diagnosis) unable to perform the study procedures

illness severe enough to require hospitalization or already meeting study's primary endpoint for clinical worsening. unstable medical comorbidities including, but not limited to: severe underlying lung disease (copd on home oxygen, interstitial lung disease, pulmonary hypertension), decompensated cirrhosis, congestive heart failure (stage 3 or 4 per patient report and/or medical records). immunocompromised (solid organ transplant, bmt, aids, on biologics and/or high dose steroids (>20mg prednisone per day) unable to provide informed consent (eg moderate-severe dementia diagnosis) unable to perform the study procedures

1. illness severe enough to require hospitalization or already meeting study's primary endpoint for clinical worsening. 2. unstable medical comorbidities including, but not limited to: severe underlying lung disease (copd on home oxygen, interstitial lung disease, pulmonary hypertension), decompensated cirrhosis, congestive heart failure (stage 3 or 4 per patient report and/or medical records). 3. immunocompromised (solid organ transplant, bmt, aids, on biologics and/or high dose steroids (>20mg prednisone per day) 4. unable to provide informed consent (eg moderate-severe dementia diagnosis) 5. unable to perform the study procedures

1. illness severe enough to require hospitalization or already meeting study's primary endpoint for clinical worsening. 2. unstable medical comorbidities including, but not limited to: severe underlying lung disease (copd on home oxygen, interstitial lung disease, pulmonary hypertension), decompensated cirrhosis, congestive heart failure (stage 3 or 4 per patient report and/or medical records). 3. immunocompromised (solid organ transplant, bmt, aids, on biologics and/or high dose steroids (>20mg prednisone per day) 4. unable to provide informed consent (eg moderate-severe dementia diagnosis) 5. unable to perform the study procedures