inclusion criteria: the inclusion criteria corresponding to the risk group consist of: - participants that present hypertension or diabetes mellitus before pregnancy - bmi >35 - family history of preeclampsia or diabetes - macrosomic previous baby - bmi< 20 - history of pretem delivery - previous intrauterine growth restriction or gestational mellitus diabetes history - maternal age <16 years or > 40 years - history maternal infection. the inclusion criteria for healthy participants are: - patients between 10-12 weeks of gestation - bmi between 20 to 30.

inclusion criteria: the inclusion criteria corresponding to the risk group consist of: - participants that present hypertension or diabetes mellitus before pregnancy - bmi >35 - family history of preeclampsia or diabetes - macrosomic previous baby - bmi< 20 - history of pretem delivery - previous intrauterine growth restriction or gestational mellitus diabetes history - maternal age <16 years or > 40 years - history maternal infection. the inclusion criteria for healthy participants are: - patients between 10-12 weeks of gestation - bmi between 20 to 30.