- contraindication or allergy to chloroquine, hydroxychloroquine or azithromycin - current use hydroxychloroquine, chloroquine or azithromycin - concurrent use of another investigational agent - invasive mechanical ventilation - participants who have any severe and/or uncontrolled medical conditions such as: - unstable angina pectoris, - symptomatic congestive heart failure, - myocardial infarction, - cardiac arrhythmias or know prolonged qtc >470 males, >480 female on ecg - pulmonary insufficiency, - epilepsy (interaction with chloroquine), - prior retinal eye disease - concurrent malignancy requiring chemotherapy - known chronic kidney disease, egfr<10 or dialysis - g-6-pd deficiency, if unknown requires g6pd testing prior to enrollment - known porphyria - known myasthenia gravis - currently pregnant or planning on getting pregnant while on study - breast feeding - ast/alt >five times the upper limit of normal uln* - bilirubin >five times the uln* - magnesium <1.4 meq/l* - calcium <8.4mg/dl >10.6mg/dl* - potassium <3.3 >5.5 meg/l*

- contraindication or allergy to chloroquine, hydroxychloroquine or azithromycin - current use hydroxychloroquine, chloroquine or azithromycin - concurrent use of another investigational agent - invasive mechanical ventilation - participants who have any severe and/or uncontrolled medical conditions such as: - unstable angina pectoris, - symptomatic congestive heart failure, - myocardial infarction, - cardiac arrhythmias or know prolonged qtc >470 males, >480 female on ecg - pulmonary insufficiency, - epilepsy (interaction with chloroquine), - prior retinal eye disease - concurrent malignancy requiring chemotherapy - known chronic kidney disease, egfr<10 or dialysis - g-6-pd deficiency, if unknown requires g6pd testing prior to enrollment - known porphyria - known myasthenia gravis - currently pregnant or planning on getting pregnant while on study - breast feeding - ast/alt >five times the upper limit of normal uln* - bilirubin >five times the uln* - magnesium <1.4 meq/l* - calcium <8.4mg/dl >10.6mg/dl* - potassium <3.3 >5.5 meg/l*