inclusion criteria: - informed consent given - male and female patients age 18 years or older - patients with coronavirus (sars-cov-2) infection confirmed prior to enrollment by any test with local regulatory approval - patients who require intensive care as determined by the following objective criteria: - respiratory rate>25/minute - oxygen saturation <93% on room air; or the - use of high flow oxygen by nasal cannula at a rate ≥ 4l/minute. - patients with lung imaging demonstrating bilateral or diffuse pulmonary infiltrates on chest x-ray or ct scan. - patients with moderate to severe ards as defined by berlin criteria - patients who require invasive mechanical ventilation (imv)

inclusion criteria: - informed consent given - male and female patients age 18 years or older - patients with coronavirus (sars-cov-2) infection confirmed prior to enrollment by any test with local regulatory approval - patients who require intensive care as determined by the following objective criteria: - respiratory rate>25/minute - oxygen saturation <93% on room air; or the - use of high flow oxygen by nasal cannula at a rate ≥ 4l/minute. - patients with lung imaging demonstrating bilateral or diffuse pulmonary infiltrates on chest x-ray or ct scan. - patients with moderate to severe ards as defined by berlin criteria - patients who require invasive mechanical ventilation (imv)