- patients that have need for additional immunosuppressive treatment - patients with any past (within the past 3-5 years) or present malignancy (other than excised basal cell carcinoma). - co-infection with other infectious agent. - females capable of becoming pregnant must have a negative pregnancy test prior to treatment. after inclusion, they must use contraceptives for 2 months following the given stem cell treatment. the pill, spiral, depot injection of progesterone, sub-dermal implantation, hormonal vaginal ring and transdermal patch regarded as safe contraceptives. - patients who are participating in other clinical trials.

- patients that have need for additional immunosuppressive treatment - patients with any past (within the past 3-5 years) or present malignancy (other than excised basal cell carcinoma). - co-infection with other infectious agent. - females capable of becoming pregnant must have a negative pregnancy test prior to treatment. after inclusion, they must use contraceptives for 2 months following the given stem cell treatment. the pill, spiral, depot injection of progesterone, sub-dermal implantation, hormonal vaginal ring and transdermal patch regarded as safe contraceptives. - patients who are participating in other clinical trials.