oxygen requirement at home due to chronic lung disease. patients with immunosuppression or immunosuppressive therapies defined as: cancer on active chemotherapy. stem cell transplant in the previous 6 months. neutrophil count < 1000 cells/mm3. chronic treatment with immunosuppressive therapy, except for low-dose (≤10 mg daily) prednisone or equivalent dose of other corticosteroids. hiv-infected patients with cd4 < 200 x 106/l. diagnosis with primary immunodeficiencies. chronic liver damage child-pugh c. chronic underlying process with suspected life expectancy less than 12 weeks. uncontrolled diabetes mellitus at screening, defined as no blood glucose testing or any blood glucose level higher than 14 mmol/l (or 250 mg/dl) in the last 14 days. diagnosis of any form of psychosis without receiving appropriate treatment. pregnancy at time of randomization.

oxygen requirement at home due to chronic lung disease. patients with immunosuppression or immunosuppressive therapies defined as: cancer on active chemotherapy. stem cell transplant in the previous 6 months. neutrophil count < 1000 cells/mm3. chronic treatment with immunosuppressive therapy, except for low-dose (≤10 mg daily) prednisone or equivalent dose of other corticosteroids. hiv-infected patients with cd4 < 200 x 106/l. diagnosis with primary immunodeficiencies. chronic liver damage child-pugh c. chronic underlying process with suspected life expectancy less than 12 weeks. uncontrolled diabetes mellitus at screening, defined as no blood glucose testing or any blood glucose level higher than 14 mmol/l (or 250 mg/dl) in the last 14 days. diagnosis of any form of psychosis without receiving appropriate treatment. pregnancy at time of randomization.

1. oxygen requirement at home due to chronic lung disease. 2. patients with immunosuppression or immunosuppressive therapies defined as: - cancer on active chemotherapy. - stem cell transplant in the previous 6 months. - neutrophil count < 1000 cells/mm3. - chronic treatment with immunosuppressive therapy, except for low-dose (≤10 mg daily) prednisone or equivalent dose of other corticosteroids. - hiv-infected patients with cd4 < 200 x 106/l. - diagnosis with primary immunodeficiencies. 3. chronic liver damage child-pugh c. 4. chronic underlying process with suspected life expectancy less than 12 weeks. 5. uncontrolled diabetes mellitus at screening, defined as no blood glucose testing or any blood glucose level higher than 14 mmol/l (or 250 mg/dl) in the last 14 days. 6. diagnosis of any form of psychosis without receiving appropriate treatment. 7. pregnancy at time of randomization.

1. oxygen requirement at home due to chronic lung disease. 2. patients with immunosuppression or immunosuppressive therapies defined as: - cancer on active chemotherapy. - stem cell transplant in the previous 6 months. - neutrophil count < 1000 cells/mm3. - chronic treatment with immunosuppressive therapy, except for low-dose (≤10 mg daily) prednisone or equivalent dose of other corticosteroids. - hiv-infected patients with cd4 < 200 x 106/l. - diagnosis with primary immunodeficiencies. 3. chronic liver damage child-pugh c. 4. chronic underlying process with suspected life expectancy less than 12 weeks. 5. uncontrolled diabetes mellitus at screening, defined as no blood glucose testing or any blood glucose level higher than 14 mmol/l (or 250 mg/dl) in the last 14 days. 6. diagnosis of any form of psychosis without receiving appropriate treatment. 7. pregnancy at time of randomization.

1. oxygen requirement at home due to chronic lung disease. 2. patients with immunosuppression or immunosuppressive therapies defined as: - cancer on active chemotherapy. - stem cell transplant in the previous 6 months. - neutrophil count < 1000 cells/mm3. - chronic treatment with immunosuppressive therapy, except for low-dose (≤10 mg daily) prednisone or equivalent dose of other corticosteroids. - hiv-infected patients with cd4 < 200 x 106/l. - diagnosis with primary immunodeficiencies. 3. chronic liver damage child-pugh c. 4. chronic underlying process with suspected life expectancy less than 12 weeks. 5. uncontrolled diabetes mellitus at screening, defined as no blood glucose testing or any blood glucose level higher than 14 mmol/l (or 250 mg/dl) in the last 14 days. 6. diagnosis of any form of psychosis without receiving appropriate treatment. 7. pregnancy at time of randomization. 8. patients who received approved or trial vaccination for sars-cov-2.

1. oxygen requirement at home due to chronic lung disease. 2. patients with immunosuppression or immunosuppressive therapies defined as: - cancer on active chemotherapy. - stem cell transplant in the previous 6 months. - neutrophil count < 1000 cells/mm3. - chronic treatment with immunosuppressive therapy, except for low-dose (≤10 mg daily) prednisone or equivalent dose of other corticosteroids. - hiv-infected patients with cd4 < 200 x 106/l. - diagnosis with primary immunodeficiencies. 3. chronic liver damage child-pugh c. 4. chronic underlying process with suspected life expectancy less than 12 weeks. 5. uncontrolled diabetes mellitus at screening, defined as no blood glucose testing or any blood glucose level higher than 14 mmol/l (or 250 mg/dl) in the last 14 days. 6. diagnosis of any form of psychosis without receiving appropriate treatment. 7. pregnancy at time of randomization. 8. patients who received approved or trial vaccination for sars-cov-2.