- use of oral anticoagulation drugs; patients may be included when they have been switched to lmwh - patients on vitamin k antagonists with a supra-therapeutic anticoagulation at admission who require vitamin k supplementation to correct this, or were administered vitamin k for this reason within the preceding 5 days - patients already using vitamin k supplements at admission - participation in another intervention study - direct admission to an intensive care unit (icu) for invasive ventilation at presentation - confirmed active pulmonary embolism or deep venous thrombosis prior to inclusion - known allergy to any of the components of the study medication or placebo - patients who are hemodialysis dependent at admission - pregnancy at the time of inclusion - diagnosed malignancy at the time of inclusion

- use of oral anticoagulation drugs; patients may be included when they have been switched to lmwh - patients on vitamin k antagonists with a supra-therapeutic anticoagulation at admission who require vitamin k supplementation to correct this, or were administered vitamin k for this reason within the preceding 5 days - patients already using vitamin k supplements at admission - participation in another intervention study - direct admission to an intensive care unit (icu) for invasive ventilation at presentation - confirmed active pulmonary embolism or deep venous thrombosis prior to inclusion - known allergy to any of the components of the study medication or placebo - patients who are hemodialysis dependent at admission - pregnancy at the time of inclusion - diagnosed malignancy at the time of inclusion