- life expectancy ≤ 24h - glomerular filtration ≤ 30 ml / min / 1.73 m2 - leukopenia ≤ 4000 cells / µl - concomitant potentially serious infections. - contraindication for the use of tacrolimus according to the specifications of the product - known adverse reactions to treatment - have participated in a clinical trial in the last 3 months

- life expectancy ≤ 24h - glomerular filtration ≤ 30 ml / min / 1.73 m2 - leukopenia ≤ 4000 cells / µl - concomitant potentially serious infections. - contraindication for the use of tacrolimus according to the specifications of the product - known adverse reactions to treatment - have participated in a clinical trial in the last 3 months