- ventilated intubated patients - patient with advanced cancer and without curative possibility - bacterial or viral (hiv) infection explaining the worsening (the main reason) - body mass index > 40 - impossibility to put a central venous catheter according to investigator's judgement - severe hemodynamic instability with mean arterial pressure < 65 mmhg (whatever the noradrenaline dosage used) - immunoglobulin a (iga) deficiency with anti-iga antibodies - inclusion in another study that could interact with the covidep study (investigator's judgement) - patient under legal protection measure - pregnant or breastfeeding women - in case of allergy to amotosalen (psoralens) or ai-ffp (amotosalen inactivated fresh frozen plasma) , use se-ffp (secured fresh frozen plasma)

- ventilated intubated patients - patient with advanced cancer and without curative possibility - bacterial or viral (hiv) infection explaining the worsening (the main reason) - body mass index > 40 - impossibility to put a central venous catheter according to investigator's judgement - severe hemodynamic instability with mean arterial pressure < 65 mmhg (whatever the noradrenaline dosage used) - immunoglobulin a (iga) deficiency with anti-iga antibodies - inclusion in another study that could interact with the covidep study (investigator's judgement) - patient under legal protection measure - pregnant or breastfeeding women - in case of allergy to amotosalen (psoralens) or ai-ffp (amotosalen inactivated fresh frozen plasma) , use se-ffp (secured fresh frozen plasma)