- plan for palliation within 24 hours - known allergy to study medication or its components (non-medicinal ingredients) - ordinal scale 6 or above - admitted to facility for non-medical reasons including primary psychiatric diagnosis or labour and delivery. - pregnancy or breast feeding - weight less than 40kg

- plan for palliation within 24 hours - known allergy to study medication or its components (non-medicinal ingredients) - ordinal scale 6 or above - admitted to facility for non-medical reasons including primary psychiatric diagnosis or labour and delivery. - pregnancy or breast feeding - weight less than 40kg