master protocol inclusion criteria: adults (≥18 years) with laboratory-confirmed* sars-cov-2 infection (pcr) ability to provide informed consent signed by study patient or legally acceptable representative women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use a highly effective method of contraception (as outlined in the protocol) from the first administration of trial treatment, throughout trial treatment and for the duration outlined in the candidate-specific trial protocol after the last dose of trial treatment if any csts are included in the community setting, the cst protocol will clarify whether patients with suspected sars-cov-2 infection are also eligible. standard additional criteria that may be applied per cst protocol: group a (severe disease) 4a. patients with clinical status of grades 4 (hospitalised, oxygen by mask or nasal prongs), 5 (hospitalised, on non-invasive ventilation, or high flow oxygen), 6 (hospitalised, intubation and mechanical ventilation) or 7 (ventilation and additional organ support - pressors, renal replacement therapy (rrt), extracorporeal membrane oxygenation (ecmo)), as defined by the who clinical severity score, 9-point ordinal scale. group b (mild-moderate disease) 4b. ambulant or hospitalised patients with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra n.b. the cst protocol inclusion criteria will take precedence over the master protocol inclusion criteria. cst-2 inclusion criteria: for the purpose of the eidd-2801 candidate-specific trial the following inclusion criteria have been amended from the master protocol to: 1. male or female ≥ 60 years old or ≥50 years old with at least one well controlled comorbidity: cardiovascular disease, chronic lung disease (e.g. copd, or pulmonary hypertension), immune deficiency (taking the equivalent of 20 mg prednisone daily, chemotherapy, or immune modulating biologic therapies), diabetes (treated with insulin or oral medications), bmi≥30, or hypertension requiring medication with laboratory confirmed sars-cov-2 infection (pcr) . 3. women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use two effective methods of contraception, one of which should be highly effective (as outlined in the protocol). for women, from the first administration of trial treatment, throughout trial and up to 50 days after the last follow up visit (50 days after day 29) and for men with female partners of child bearing potential, from the first administration until 100 days after last follow up visit (100 days after day 29). 4. group b (mild-moderate disease): ambulant with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra (nb this differs to the master protocol which also includes hospitalised patients in this group). additional criteria specific to this candidate are: 5. has signs or symptoms of covid-19 that began within 5 days of the planned first dose of study drug. 6. is in generally good health (except for current respiratory infection) and is free of uncontrolled chronic conditions. 7. is willing and able to comply with all study procedures and attending clinic visits through the 4th week. 8. has someone, aged ≥ 16 living in the same household during the dosing period. cst-6 additional inclusion criteria: group a (severe disease). patients with clinical status of grades 5 (hospitalised, oxygen by mask or nasal prongs), 6 (hospitalised, on non-invasive ventilation, or high flow oxygen as defined by the who clinical progression scale (who, 2020)). less than or equal to 14 days from onset of covid-19 symptoms master protocol

master protocol inclusion criteria: adults (≥18 years) with laboratory-confirmed* sars-cov-2 infection (pcr) ability to provide informed consent signed by study patient or legally acceptable representative women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use a highly effective method of contraception (as outlined in the protocol) from the first administration of trial treatment, throughout trial treatment and for the duration outlined in the candidate-specific trial protocol after the last dose of trial treatment if any csts are included in the community setting, the cst protocol will clarify whether patients with suspected sars-cov-2 infection are also eligible. standard additional criteria that may be applied per cst protocol: group a (severe disease) 4a. patients with clinical status of grades 4 (hospitalised, oxygen by mask or nasal prongs), 5 (hospitalised, on non-invasive ventilation, or high flow oxygen), 6 (hospitalised, intubation and mechanical ventilation) or 7 (ventilation and additional organ support - pressors, renal replacement therapy (rrt), extracorporeal membrane oxygenation (ecmo)), as defined by the who clinical severity score, 9-point ordinal scale. group b (mild-moderate disease) 4b. ambulant or hospitalised patients with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra n.b. the cst protocol inclusion criteria will take precedence over the master protocol inclusion criteria. cst-2 inclusion criteria: for the purpose of the eidd-2801 candidate-specific trial the following inclusion criteria have been amended from the master protocol to: 1. male or female ≥ 60 years old or ≥50 years old with at least one well controlled comorbidity: cardiovascular disease, chronic lung disease (e.g. copd, or pulmonary hypertension), immune deficiency (taking the equivalent of 20 mg prednisone daily, chemotherapy, or immune modulating biologic therapies), diabetes (treated with insulin or oral medications), bmi≥30, or hypertension requiring medication with laboratory confirmed sars-cov-2 infection (pcr) . 3. women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use two effective methods of contraception, one of which should be highly effective (as outlined in the protocol). for women, from the first administration of trial treatment, throughout trial and up to 50 days after the last follow up visit (50 days after day 29) and for men with female partners of child bearing potential, from the first administration until 100 days after last follow up visit (100 days after day 29). 4. group b (mild-moderate disease): ambulant with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra (nb this differs to the master protocol which also includes hospitalised patients in this group). additional criteria specific to this candidate are: 5. has signs or symptoms of covid-19 that began within 5 days of the planned first dose of study drug. 6. is in generally good health (except for current respiratory infection) and is free of uncontrolled chronic conditions. 7. is willing and able to comply with all study procedures and attending clinic visits through the 4th week. 8. has someone, aged ≥ 16 living in the same household during the dosing period. cst-6 additional inclusion criteria: group a (severe disease). patients with clinical status of grades 5 (hospitalised, oxygen by mask or nasal prongs), 6 (hospitalised, on non-invasive ventilation, or high flow oxygen as defined by the who clinical progression scale (who, 2020)). less than or equal to 14 days from onset of covid-19 symptoms master protocol

master protocol inclusion criteria: adults (≥18 years) with laboratory-confirmed* sars-cov-2 infection (pcr) ability to provide informed consent signed by study patient or legally acceptable representative women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use a highly effective method of contraception (as outlined in the protocol) from the first administration of trial treatment, throughout trial treatment and for the duration outlined in the candidate-specific trial protocol after the last dose of trial treatment if any csts are included in the community setting, the cst protocol will clarify whether patients with suspected sars-cov-2 infection are also eligible. standard additional criteria that may be applied per cst protocol: group a (severe disease) 4a. patients with clinical status of grades 4 (hospitalised, oxygen by mask or nasal prongs), 5 (hospitalised, on non-invasive ventilation, or high flow oxygen), 6 (hospitalised, intubation and mechanical ventilation) or 7 (ventilation and additional organ support - pressors, renal replacement therapy (rrt), extracorporeal membrane oxygenation (ecmo)), as defined by the who clinical severity score, 9-point ordinal scale. group b (mild-moderate disease) 4b. ambulant or hospitalised patients with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra n.b. the cst protocol inclusion criteria will take precedence over the master protocol inclusion criteria. cst-2 inclusion criteria: for the purpose of the eidd-2801 candidate-specific trial the following inclusion criteria have been amended from the master protocol to: 1. male or female ≥ 60 years old or ≥50 years old with at least one well controlled comorbidity: cardiovascular disease, chronic lung disease (e.g. copd, or pulmonary hypertension), immune deficiency (taking the equivalent of 20 mg prednisone daily, chemotherapy, or immune modulating biologic therapies), diabetes (treated with insulin or oral medications), bmi≥30, or hypertension requiring medication with laboratory confirmed sars-cov-2 infection (pcr) . 3. women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use two effective methods of contraception, one of which should be highly effective (as outlined in the protocol). for women, from the first administration of trial treatment, throughout trial and up to 50 days after the last follow up visit (50 days after day 29) and for men with female partners of child bearing potential, from the first administration until 100 days after last follow up visit (100 days after day 29). 4. group b (mild-moderate disease): ambulant with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra (nb this differs to the master protocol which also includes hospitalised patients in this group). additional criteria specific to this candidate are: 5. has signs or symptoms of covid-19 that began within 5 days of the planned first dose of study drug. 6. is in generally good health (except for current respiratory infection) and is free of uncontrolled chronic conditions. 7. is willing and able to comply with all study procedures and attending clinic visits through the 4th week. 8. has someone, aged ≥ 16 living in the same household during the dosing period. master protocol

master protocol inclusion criteria: adults (≥18 years) with laboratory-confirmed* sars-cov-2 infection (pcr) ability to provide informed consent signed by study patient or legally acceptable representative women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use a highly effective method of contraception (as outlined in the protocol) from the first administration of trial treatment, throughout trial treatment and for the duration outlined in the candidate-specific trial protocol after the last dose of trial treatment if any csts are included in the community setting, the cst protocol will clarify whether patients with suspected sars-cov-2 infection are also eligible. standard additional criteria that may be applied per cst protocol: group a (severe disease) 4a. patients with clinical status of grades 4 (hospitalised, oxygen by mask or nasal prongs), 5 (hospitalised, on non-invasive ventilation, or high flow oxygen), 6 (hospitalised, intubation and mechanical ventilation) or 7 (ventilation and additional organ support - pressors, renal replacement therapy (rrt), extracorporeal membrane oxygenation (ecmo)), as defined by the who clinical severity score, 9-point ordinal scale. group b (mild-moderate disease) 4b. ambulant or hospitalised patients with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra n.b. the cst protocol inclusion criteria will take precedence over the master protocol inclusion criteria. cst-2 inclusion criteria: for the purpose of the eidd-2801 candidate-specific trial the following inclusion criteria have been amended from the master protocol to: 1. male or female ≥ 60 years old or ≥50 years old with at least one well controlled comorbidity: cardiovascular disease, chronic lung disease (e.g. copd, or pulmonary hypertension), immune deficiency (taking the equivalent of 20 mg prednisone daily, chemotherapy, or immune modulating biologic therapies), diabetes (treated with insulin or oral medications), bmi≥30, or hypertension requiring medication with laboratory confirmed sars-cov-2 infection (pcr) . 3. women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use two effective methods of contraception, one of which should be highly effective (as outlined in the protocol). for women, from the first administration of trial treatment, throughout trial and up to 50 days after the last follow up visit (50 days after day 29) and for men with female partners of child bearing potential, from the first administration until 100 days after last follow up visit (100 days after day 29). 4. group b (mild-moderate disease): ambulant with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra (nb this differs to the master protocol which also includes hospitalised patients in this group). additional criteria specific to this candidate are: 5. has signs or symptoms of covid-19 that began within 5 days of the planned first dose of study drug. 6. is in generally good health (except for current respiratory infection) and is free of uncontrolled chronic conditions. 7. is willing and able to comply with all study procedures and attending clinic visits through the 4th week. 8. has someone, aged ≥ 16 living in the same household during the dosing period. master protocol

master protocol inclusion criteria: 1. adults (≥18 years) with laboratory-confirmed* sars-cov-2 infection (pcr) 2. ability to provide informed consent signed by study patient or legally acceptable representative 3. women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use a highly effective method of contraception (as outlined in the protocol) from the first administration of trial treatment, throughout trial treatment and for the duration outlined in the candidate-specific trial protocol after the last dose of trial treatment - if any csts are included in the community setting, the cst protocol will clarify whether patients with suspected sars-cov-2 infection are also eligible. standard additional criteria that may be applied per cst protocol: group a (severe disease) 4a. patients with clinical status of grades 4 (hospitalised, oxygen by mask or nasal prongs), 5 (hospitalised, on non-invasive ventilation, or high flow oxygen), 6 (hospitalised, intubation and mechanical ventilation) or 7 (ventilation and additional organ support - pressors, renal replacement therapy (rrt), extracorporeal membrane oxygenation (ecmo)), as defined by the who clinical severity score, 9-point ordinal scale. group b (mild-moderate disease) 4b. ambulant or hospitalised patients with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra n.b. the cst protocol inclusion criteria will take precedence over the master protocol inclusion criteria. cst-2 inclusion criteria: for the purpose of the eidd-2801 candidate-specific trial the following inclusion criteria have been amended from the master protocol to: 1. male or female ≥ 60 years old or ≥50 years old with at least one well controlled comorbidity: cardiovascular disease, chronic lung disease (e.g. copd, or pulmonary hypertension), immune deficiency (taking the equivalent of 20 mg prednisone daily, chemotherapy, or immune modulating biologic therapies), diabetes (treated with insulin or oral medications), bmi≥30, or hypertension requiring medication with laboratory confirmed sars-cov-2 infection (pcr) . 3. women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use two effective methods of contraception, one of which should be highly effective (as outlined in the protocol). for women, from the first administration of trial treatment, throughout trial and up to 50 days after the last follow up visit (50 days after day 29) and for men with female partners of child bearing potential, from the first administration until 100 days after last follow up visit (100 days after day 29). 4. group b (mild-moderate disease): ambulant with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra (nb this differs to the master protocol which also includes hospitalised patients in this group). additional criteria specific to this candidate are: 5. has signs or symptoms of covid-19 that began within 5 days of the planned first dose of study drug. 6. is in generally good health (except for current respiratory infection) and is free of uncontrolled chronic conditions. 7. is willing and able to comply with all study procedures and attending clinic visits through the 4th week. 8. has someone, aged ≥ 16 living in the same household during the dosing period. master protocol

master protocol inclusion criteria: 1. adults (≥18 years) with laboratory-confirmed* sars-cov-2 infection (pcr) 2. ability to provide informed consent signed by study patient or legally acceptable representative 3. women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use a highly effective method of contraception (as outlined in the protocol) from the first administration of trial treatment, throughout trial treatment and for the duration outlined in the candidate-specific trial protocol after the last dose of trial treatment - if any csts are included in the community setting, the cst protocol will clarify whether patients with suspected sars-cov-2 infection are also eligible. standard additional criteria that may be applied per cst protocol: group a (severe disease) 4a. patients with clinical status of grades 4 (hospitalised, oxygen by mask or nasal prongs), 5 (hospitalised, on non-invasive ventilation, or high flow oxygen), 6 (hospitalised, intubation and mechanical ventilation) or 7 (ventilation and additional organ support - pressors, renal replacement therapy (rrt), extracorporeal membrane oxygenation (ecmo)), as defined by the who clinical severity score, 9-point ordinal scale. group b (mild-moderate disease) 4b. ambulant or hospitalised patients with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra n.b. the cst protocol inclusion criteria will take precedence over the master protocol inclusion criteria. cst-2 inclusion criteria: for the purpose of the eidd-2801 candidate-specific trial the following inclusion criteria have been amended from the master protocol to: 1. male or female ≥ 60 years old or ≥50 years old with at least one well controlled comorbidity: cardiovascular disease, chronic lung disease (e.g. copd, or pulmonary hypertension), immune deficiency (taking the equivalent of 20 mg prednisone daily, chemotherapy, or immune modulating biologic therapies), diabetes (treated with insulin or oral medications), bmi≥30, or hypertension requiring medication with laboratory confirmed sars-cov-2 infection (pcr) . 3. women of childbearing potential (wocbp) and male patients who are sexually active with wocbp must agree to use two effective methods of contraception, one of which should be highly effective (as outlined in the protocol). for women, from the first administration of trial treatment, throughout trial and up to 50 days after the last follow up visit (50 days after day 29) and for men with female partners of child bearing potential, from the first administration until 100 days after last follow up visit (100 days after day 29). 4. group b (mild-moderate disease): ambulant with the following characteristics peripheral capillary oxygen saturation (spo2) >94% ra (nb this differs to the master protocol which also includes hospitalised patients in this group). additional criteria specific to this candidate are: 5. has signs or symptoms of covid-19 that began within 5 days of the planned first dose of study drug. 6. is in generally good health (except for current respiratory infection) and is free of uncontrolled chronic conditions. 7. is willing and able to comply with all study procedures and attending clinic visits through the 4th week. 8. has someone, aged ≥ 16 living in the same household during the dosing period. master protocol