inclusion criteria: subjects must meet the following criteria to be included in the study: male or females between 18-80 years of age at the time of consent. laboratory-confirmed covid-19 infection hospitalized for covid-19 with clinical evidence of respiratory involvement, including at least one of the following: symptoms/signs: cough, respiratory distress, increased work of breathing radiology: chest radiograph or other chest imaging demonstrating one of bronchial thickening, increased secretions, hyperinflation, infiltrates hypoxemia in room air, spo2 ≤ 90% patient belongs to one of the following two categories in the seven-point covid-19 severity scale: requiring supplemental oxygen by nasal prongs - level 4 of the seven-point covid-19 severity scale; requiring nasal high-flow oxygen therapy,- limited to this one component of level 5 of the seven-point covid-19 severity scale. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. ability to sign informed consent or, when patient is not capable of doing so, informed consent can be signed by legal/authorized representative

inclusion criteria: subjects must meet the following criteria to be included in the study: male or females between 18-80 years of age at the time of consent. laboratory-confirmed covid-19 infection hospitalized for covid-19 with clinical evidence of respiratory involvement, including at least one of the following: symptoms/signs: cough, respiratory distress, increased work of breathing radiology: chest radiograph or other chest imaging demonstrating one of bronchial thickening, increased secretions, hyperinflation, infiltrates hypoxemia in room air, spo2 ≤ 90% patient belongs to one of the following two categories in the seven-point covid-19 severity scale: requiring supplemental oxygen by nasal prongs - level 4 of the seven-point covid-19 severity scale; requiring nasal high-flow oxygen therapy,- limited to this one component of level 5 of the seven-point covid-19 severity scale. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. ability to sign informed consent or, when patient is not capable of doing so, informed consent can be signed by legal/authorized representative

inclusion criteria: - subjects must meet the following criteria to be included in the study: 1. male or females between 18-80 years of age at the time of consent. 2. laboratory-confirmed covid-19 infection 3. hospitalized for covid-19 with clinical evidence of respiratory involvement, including at least one of the following: 1. symptoms/signs: cough, respiratory distress, increased work of breathing 2. radiology: chest radiograph or other chest imaging demonstrating one of bronchial thickening, increased secretions, hyperinflation, infiltrates 4. hypoxemia in room air, spo2 ≤ 90% 5. patient belongs to one of the following two categories in the seven-point covid-19 severity scale: 1. requiring supplemental oxygen by nasal prongs - level 4 of the seven-point covid-19 severity scale; 2. requiring nasal high-flow oxygen therapy,- limited to this one component of level 5 of the seven-point covid-19 severity scale. 6. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. 7. ability to sign informed consent or, when patient is not capable of doing so, informed consent can be signed by legal/authorized representative

inclusion criteria: - subjects must meet the following criteria to be included in the study: 1. male or females between 18-80 years of age at the time of consent. 2. laboratory-confirmed covid-19 infection 3. hospitalized for covid-19 with clinical evidence of respiratory involvement, including at least one of the following: 1. symptoms/signs: cough, respiratory distress, increased work of breathing 2. radiology: chest radiograph or other chest imaging demonstrating one of bronchial thickening, increased secretions, hyperinflation, infiltrates 4. hypoxemia in room air, spo2 ≤ 90% 5. patient belongs to one of the following two categories in the seven-point covid-19 severity scale: 1. requiring supplemental oxygen by nasal prongs - level 4 of the seven-point covid-19 severity scale; 2. requiring nasal high-flow oxygen therapy,- limited to this one component of level 5 of the seven-point covid-19 severity scale. 6. for women of childbearing potential involved in any sexual intercourse that could lead to pregnancy: negative pregnancy test and willingness to use contraceptive (consistent with local regulations) during the study period. 7. ability to sign informed consent or, when patient is not capable of doing so, informed consent can be signed by legal/authorized representative