- known severe allergic reactions to tocilizumab or any other monoclonal antibody - pregnancy or breastfeeding - absolute neutrophil count(anc) < 1000 - alanine aminotransferase(alt) or aspartate aminotransferase (ast) > 5 times upper normal limit - platelet count of < 50,000 - bowel diverticulitis or bowel perforation - patients having acute pancreatitis

- known severe allergic reactions to tocilizumab or any other monoclonal antibody - pregnancy or breastfeeding - absolute neutrophil count(anc) < 1000 - alanine aminotransferase(alt) or aspartate aminotransferase (ast) > 5 times upper normal limit - platelet count of < 50,000 - bowel diverticulitis or bowel perforation - patients having acute pancreatitis