- age <18 years; - refuse to sign the informed consent form; - patient's decision that their involvement is not in their interest; - severe known liver disease (eg cirrhosis, with aminotransferase levels> 5 times the reference value limit); - pregnancy or breastfeeding period; - severe bacterial infection; - severe diarrhea; - diverticulitis or intestinal perforation; - infection known as hiv; - presence of one of the following uncontrolled or unstable cardiovascular diseases: stroke, ecg confirmed acute ischemia or myocardial infarction and / or clinically significant dysrhythmia; • known history of gastrointestinal bleeding, uncontrolled peptic ulcer or uncontrolled duodenal ulcer; - known history of hemophilia or other bleeding disorders; - history of organ transplantation, congenital immunodeficiency;

- age <18 years; - refuse to sign the informed consent form; - patient's decision that their involvement is not in their interest; - severe known liver disease (eg cirrhosis, with aminotransferase levels> 5 times the reference value limit); - pregnancy or breastfeeding period; - severe bacterial infection; - severe diarrhea; - diverticulitis or intestinal perforation; - infection known as hiv; - presence of one of the following uncontrolled or unstable cardiovascular diseases: stroke, ecg confirmed acute ischemia or myocardial infarction and / or clinically significant dysrhythmia; • known history of gastrointestinal bleeding, uncontrolled peptic ulcer or uncontrolled duodenal ulcer; - known history of hemophilia or other bleeding disorders; - history of organ transplantation, congenital immunodeficiency;