- respiratory failure requiring mechanical ventilation - intensive care unit admission - neutrophile con. < 1000 cells/mm3 - lymphocyte con < 500 cells/mm3 - liver enzymes 5 times higher then the norm - qt interval longer then 500 ms. - pregnancy - hemodialysis renal replacement therapy - active or prior psychotic event

- respiratory failure requiring mechanical ventilation - intensive care unit admission - neutrophile con. < 1000 cells/mm3 - lymphocyte con < 500 cells/mm3 - liver enzymes 5 times higher then the norm - qt interval longer then 500 ms. - pregnancy - hemodialysis renal replacement therapy - active or prior psychotic event