- participants with uncontrolled clinical status who were hospitalized from the before. - contraindication / possible drug interaction. - participants who have any severe and/or uncontrolled medical conditions like, severe ischemic heart disease, epilepsy, malignancy, pulmonary/renal/hepatic disease, aids, pulmonary tb, pregnancy, corpulmonale, and etc.

- participants with uncontrolled clinical status who were hospitalized from the before. - contraindication / possible drug interaction. - participants who have any severe and/or uncontrolled medical conditions like, severe ischemic heart disease, epilepsy, malignancy, pulmonary/renal/hepatic disease, aids, pulmonary tb, pregnancy, corpulmonale, and etc.