inclusion criteria: age 19 to 65 years of age (phase i will be restricted to an upper age limit of 50 years of age) able to provide informed consent able and willing to comply with study procedures for women of childbearing potential, able and willing to use an approved form of pregnancy prevention through to 4 weeks post boost vaccination

inclusion criteria: age 19 to 65 years of age (phase i will be restricted to an upper age limit of 50 years of age) able to provide informed consent able and willing to comply with study procedures for women of childbearing potential, able and willing to use an approved form of pregnancy prevention through to 4 weeks post boost vaccination

inclusion criteria: 1. age 19 to 65 years of age (phase i will be restricted to an upper age limit of 50 years of age) 2. able to provide informed consent 3. able and willing to comply with study procedures 4. for women of childbearing potential, able and willing to use an approved form of pregnancy prevention through to 4 weeks post boost vaccination

inclusion criteria: 1. age 19 to 65 years of age (phase i will be restricted to an upper age limit of 50 years of age) 2. able to provide informed consent 3. able and willing to comply with study procedures 4. for women of childbearing potential, able and willing to use an approved form of pregnancy prevention through to 4 weeks post boost vaccination