inclusion criteria: subjects will be eligible for the trial if they meet all of the following criteria: adult (≥ 18 years of age) at time of enrolment; present covid-19 (infection confirmed by rt-pcr or antigen testing); intubation/mechanical ventilation or ongoing high-flow nasal cannula (hfnc) oxygen therapy; moderate or severe ards according to berlin criteria: moderate - pao2/fio2 100-200 mmhg; severe - pao2/fio2 < 100 mmhg; admission to icu in the last 24 hours.

inclusion criteria: subjects will be eligible for the trial if they meet all of the following criteria: adult (≥ 18 years of age) at time of enrolment; present covid-19 (infection confirmed by rt-pcr or antigen testing); intubation/mechanical ventilation or ongoing high-flow nasal cannula (hfnc) oxygen therapy; moderate or severe ards according to berlin criteria: moderate - pao2/fio2 100-200 mmhg; severe - pao2/fio2 < 100 mmhg; admission to icu in the last 24 hours.

inclusion criteria: subjects will be eligible for the trial if they meet all of the following criteria: 1. adult (≥ 18 years of age) at time of enrolment; 2. present covid-19 (infection confirmed by rt-pcr or antigen testing); 3. intubation/mechanical ventilation or ongoing high-flow nasal cannula (hfnc) oxygen therapy; 4. moderate or severe ards according to berlin criteria: - moderate - pao2/fio2 100-200 mmhg; - severe - pao2/fio2 < 100 mmhg; 5. admission to icu in the last 24 hours.

inclusion criteria: subjects will be eligible for the trial if they meet all of the following criteria: 1. adult (≥ 18 years of age) at time of enrolment; 2. present covid-19 (infection confirmed by rt-pcr or antigen testing); 3. intubation/mechanical ventilation or ongoing high-flow nasal cannula (hfnc) oxygen therapy; 4. moderate or severe ards according to berlin criteria: - moderate - pao2/fio2 100-200 mmhg; - severe - pao2/fio2 < 100 mmhg; 5. admission to icu in the last 24 hours.

inclusion criteria (all criteria must be fulfilled): - age > 18 years - confirmed covid-19 infection (by rt-pcr or antigen testing) - intubation/mechanical ventilation or ongoing hfnc (high-flow nasal cannula) oxygen therapy - moderate or severe ards (according to berlin criteria: moderate pao2/fio2 100 -200 mmhg, severe pao2/fio2 <100 mmhg) - admission within 24 hours to icu

inclusion criteria (all criteria must be fulfilled): - age > 18 years - confirmed covid-19 infection (by rt-pcr or antigen testing) - intubation/mechanical ventilation or ongoing hfnc (high-flow nasal cannula) oxygen therapy - moderate or severe ards (according to berlin criteria: moderate pao2/fio2 100 -200 mmhg, severe pao2/fio2 <100 mmhg) - admission within 24 hours to icu