inclusion criteria: presumptive positive laboratory test for sars-cov-2 based on local laboratory standard age greater than or equal to 18 years of age severe covid-19, defined by: a disease severity score of 3 (hospitalized, on non-invasive ventilation or high flow oxygen devices) to 4 (hospitalized, requiring supplemental oxygen). and o a respiratory sofa >=1 and increased oxygen requirement compared to baseline among those on home o2, a blood oxygen saturation of 93% or less on room air, a ratio of the partial pressure of oxygen to the fraction of inspired oxygen (pao2/fio2) of less than 300 mm hg, respiratory rate >30 breaths/min, or lung infiltrates >50% on chest ct • enrollment within 72 hours of presentation of hospital admission or within 72 hours of a positive test result, whichever is later

inclusion criteria: presumptive positive laboratory test for sars-cov-2 based on local laboratory standard age greater than or equal to 18 years of age severe covid-19, defined by: a disease severity score of 3 (hospitalized, on non-invasive ventilation or high flow oxygen devices) to 4 (hospitalized, requiring supplemental oxygen). and o a respiratory sofa >=1 and increased oxygen requirement compared to baseline among those on home o2, a blood oxygen saturation of 93% or less on room air, a ratio of the partial pressure of oxygen to the fraction of inspired oxygen (pao2/fio2) of less than 300 mm hg, respiratory rate >30 breaths/min, or lung infiltrates >50% on chest ct • enrollment within 72 hours of presentation of hospital admission or within 72 hours of a positive test result, whichever is later

inclusion criteria: - presumptive positive laboratory test for sars-cov-2 based on local laboratory standard - age greater than or equal to 18 years of age - admission to the hospital with a respiratory sofa >=1 and increased oxygen requirement compared to baseline among those on home o2 - enrollment within 72 hours of presentation of hospital admission or within 72 hours of a positive test result, whichever is later

inclusion criteria: - presumptive positive laboratory test for sars-cov-2 based on local laboratory standard - age greater than or equal to 18 years of age - admission to the hospital with a respiratory sofa >=1 and increased oxygen requirement compared to baseline among those on home o2 - enrollment within 72 hours of presentation of hospital admission or within 72 hours of a positive test result, whichever is later