- minor patient, - patient deprived of liberty, - refusal of the patient to participate in the study, - patient for whom measures of therapeutic limitation have been issued justifying the absence of recourse to mechanical ventilation, - patient of 80 years or older, - pregnant or breastfeeding woman, - patient with prior treatment with ara2 or ace inhibitors, - hypotension justifying treatment with norepinephrine, - acute renal failure with a clearance of less than 60ml/min, - severe liver failure. - intolerance or contraindication to losartan or spironolactone

- minor patient, - patient deprived of liberty, - refusal of the patient to participate in the study, - patient for whom measures of therapeutic limitation have been issued justifying the absence of recourse to mechanical ventilation, - patient of 80 years or older, - pregnant or breastfeeding woman, - patient with prior treatment with ara2 or ace inhibitors, - hypotension justifying treatment with norepinephrine, - acute renal failure with a clearance of less than 60ml/min, - severe liver failure. - intolerance or contraindication to losartan or spironolactone