- known allergic reactions to the study medication or any component of the product. - active bacterial, viral, tb, fungal infectious diseases - received immunosuppressant or immunomodulatory in the past 30 days - neutrophil count < 500 cells/microliter - platelets < 50,000/microliter - pregnant or breastfeeding females

- known allergic reactions to the study medication or any component of the product. - active bacterial, viral, tb, fungal infectious diseases - received immunosuppressant or immunomodulatory in the past 30 days - neutrophil count < 500 cells/microliter - platelets < 50,000/microliter - pregnant or breastfeeding females