inclusion criteria: - men and women aged ≥18 years - hospitalized subjects who have confirmed covid-19 infection and have evidence of pneumonia: - covid-19 infection: sars-cov-2 positive confirmed by rt-pcr - pneumonia: a reliable diagnosis of new lung infiltration on a chest ct scan or chest radiograph - subjects within 72 hours after confirmed covid-19 pneumonia - subjects with a seven-category ordinal scale of clinical status of 4 (hospitalization, requiring supplemental oxygen) or 5 (hospitalization, requiring nasal high-flow oxygen therapy and/or noninvasive mechanical ventilation) - subjects (or legally authorized representative) should be able to understand and agree to comply with the clinical trial and to provide a written consent document prior to initiation of any study procedure

inclusion criteria: - men and women aged ≥18 years - hospitalized subjects who have confirmed covid-19 infection and have evidence of pneumonia: - covid-19 infection: sars-cov-2 positive confirmed by rt-pcr - pneumonia: a reliable diagnosis of new lung infiltration on a chest ct scan or chest radiograph - subjects within 72 hours after confirmed covid-19 pneumonia - subjects with a seven-category ordinal scale of clinical status of 4 (hospitalization, requiring supplemental oxygen) or 5 (hospitalization, requiring nasal high-flow oxygen therapy and/or noninvasive mechanical ventilation) - subjects (or legally authorized representative) should be able to understand and agree to comply with the clinical trial and to provide a written consent document prior to initiation of any study procedure