- patients who had received any immuno-modulator therapy - active or chronic kidney/ liver diseases, - oncological diseases - other viral infection including hiv and hepatitis. - any allergic reaction or sensitivity to hep-1 - breast feeding or pregnancy

- patients who had received any immuno-modulator therapy - active or chronic kidney/ liver diseases, - oncological diseases - other viral infection including hiv and hepatitis. - any allergic reaction or sensitivity to hep-1 - breast feeding or pregnancy