inclusion criteria: man or woman 18 years of age or older patient with a biologically confirmed sars-cov-2 infection (by positive rt-pcr on a nasopharyngeal sample or any other sample) patient with moderate to severe ards according to the berlin definition defined by a pao2 / fio2 ratio <200 and with endotracheal intubation and under invasive mechanical ventilation patient hospitalized in the intensive care unit provision of a written informed consent to participate to the study or for whom the consent of a family member or support person has been obtained (if the patient is unable to give consent) or inclusion in an immediate vital emergency if applicable any woman of childbearing age with a negative beta hcg test social security affiliation

inclusion criteria: man or woman 18 years of age or older patient with a biologically confirmed sars-cov-2 infection (by positive rt-pcr on a nasopharyngeal sample or any other sample) patient with moderate to severe ards according to the berlin definition defined by a pao2 / fio2 ratio <200 and with endotracheal intubation and under invasive mechanical ventilation patient hospitalized in the intensive care unit provision of a written informed consent to participate to the study or for whom the consent of a family member or support person has been obtained (if the patient is unable to give consent) or inclusion in an immediate vital emergency if applicable any woman of childbearing age with a negative beta hcg test social security affiliation

inclusion criteria: 1. man or woman 18 years of age or older 2. patient with a biologically confirmed sars-cov-2 infection (by positive rt-pcr on a nasopharyngeal sample or any other sample) 3. patient with moderate to severe ards according to the berlin definition defined by a pao2 / fio2 ratio <200 and with endotracheal intubation and under invasive mechanical ventilation 4. patient hospitalized in the intensive care unit 5. provision of a written informed consent to participate to the study or for whom the consent of a family member or support person has been obtained (if the patient is unable to give consent) or inclusion in an immediate vital emergency if applicable 6. any woman of childbearing age with a negative beta hcg test 7. social security affiliation

inclusion criteria: 1. man or woman 18 years of age or older 2. patient with a biologically confirmed sars-cov-2 infection (by positive rt-pcr on a nasopharyngeal sample or any other sample) 3. patient with moderate to severe ards according to the berlin definition defined by a pao2 / fio2 ratio <200 and with endotracheal intubation and under invasive mechanical ventilation 4. patient hospitalized in the intensive care unit 5. provision of a written informed consent to participate to the study or for whom the consent of a family member or support person has been obtained (if the patient is unable to give consent) or inclusion in an immediate vital emergency if applicable 6. any woman of childbearing age with a negative beta hcg test 7. social security affiliation