age < 18 pregnant allergic to experimental drugs and patients have the following conditions: - hypercholesterolemia - hypertriglyceridemia - liver disease - renal disease - sjögren syndrome - pregnancy - lactation - depressive disorder - body mass index less than 18 points or higher than 25 points - contraindications for hormonal contraception or intrauterine device. - autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation - patients receiving anti-hcv treatment - permanent blindness in one eye - history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery - known malignant disease, psa > 3 ug/l, nycturia > 3 times - the competent physician considered it inappropriate to participate in the study

age < 18 pregnant allergic to experimental drugs and patients have the following conditions: - hypercholesterolemia - hypertriglyceridemia - liver disease - renal disease - sjögren syndrome - pregnancy - lactation - depressive disorder - body mass index less than 18 points or higher than 25 points - contraindications for hormonal contraception or intrauterine device. - autoimmune diseases a history of organ, bone marrow or hematopoietic stem cell transplantation - patients receiving anti-hcv treatment - permanent blindness in one eye - history of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery - known malignant disease, psa > 3 ug/l, nycturia > 3 times - the competent physician considered it inappropriate to participate in the study