- significant co-morbid illness with treatment escalation limited to cpap - active bleeding - pf ratio < 100 on mechanical ventilation or noradrenaline requirement > 0.5mcg/kg/min to maintain map > 65mmhg (suggests futility) - known allergies to octaplas or excipients - females who are pregnant

- significant co-morbid illness with treatment escalation limited to cpap - active bleeding - pf ratio < 100 on mechanical ventilation or noradrenaline requirement > 0.5mcg/kg/min to maintain map > 65mmhg (suggests futility) - known allergies to octaplas or excipients - females who are pregnant