mechanically ventilation for more than 4 days patient receiving drugs interfering with inflammation: non-steroidal anti-inflammatory drugs, immunoglobulins. patients receiving chemotherapy, radiotherapy or immunotherapy for malignancy participation in another interventional clinical trial pregnant or lactating women patient moribund on the day of randomization, defined by a saps-ii score>90 contra-indication for vascular access implantation for transpulmonary thermodilution monitoring severe or terminal renal insufficiency (creatinine clearance <30 ml/min) severe hepatic insufficiency (hepatic sofa score>2) severe cardiac insufficiency, with left ventricular ejection fraction<30% any history of severe allergic drug reaction (anaphylactic shock or allergic angioedema) persons deprived of their liberty by a judicial or administrative decision (guardianship or tutelage measure)

mechanically ventilation for more than 4 days patient receiving drugs interfering with inflammation: non-steroidal anti-inflammatory drugs, immunoglobulins. patients receiving chemotherapy, radiotherapy or immunotherapy for malignancy participation in another interventional clinical trial pregnant or lactating women patient moribund on the day of randomization, defined by a saps-ii score>90 contra-indication for vascular access implantation for transpulmonary thermodilution monitoring severe or terminal renal insufficiency (creatinine clearance <30 ml/min) severe hepatic insufficiency (hepatic sofa score>2) severe cardiac insufficiency, with left ventricular ejection fraction<30% any history of severe allergic drug reaction (anaphylactic shock or allergic angioedema) persons deprived of their liberty by a judicial or administrative decision (guardianship or tutelage measure)

1. mechanically ventilation for more than 4 days 2. patient receiving drugs interfering with inflammation: non-steroidal anti-inflammatory drugs, immunoglobulins. 3. patients receiving chemotherapy, radiotherapy or immunotherapy for malignancy 4. participation in another interventional clinical trial 5. pregnant or lactating women 6. patient moribund on the day of randomization, defined by a saps-ii score>90 7. contra-indication for vascular access implantation for transpulmonary thermodilution monitoring 8. severe or terminal renal insufficiency (creatinine clearance <30 ml/min) 9. severe hepatic insufficiency (hepatic sofa score>2) 10. severe cardiac insufficiency, with left ventricular ejection fraction<30% 11. any history of severe allergic drug reaction (anaphylactic shock or allergic angioedema) 12. persons deprived of their liberty by a judicial or administrative decision (guardianship or tutelage measure)

1. mechanically ventilation for more than 4 days 2. patient receiving drugs interfering with inflammation: non-steroidal anti-inflammatory drugs, immunoglobulins. 3. patients receiving chemotherapy, radiotherapy or immunotherapy for malignancy 4. participation in another interventional clinical trial 5. pregnant or lactating women 6. patient moribund on the day of randomization, defined by a saps-ii score>90 7. contra-indication for vascular access implantation for transpulmonary thermodilution monitoring 8. severe or terminal renal insufficiency (creatinine clearance <30 ml/min) 9. severe hepatic insufficiency (hepatic sofa score>2) 10. severe cardiac insufficiency, with left ventricular ejection fraction<30% 11. any history of severe allergic drug reaction (anaphylactic shock or allergic angioedema) 12. persons deprived of their liberty by a judicial or administrative decision (guardianship or tutelage measure)