inclusion criteria: - over 18 years old. - confirmed diagnosis of sars-cov-2 by polymerase chain reaction (pcr). - diagnosis of severe pneumonia according to criteria of the national institute of health and the colombian consensus (suspected respiratory infection, organ failure, arterial oxygen saturation (sao2) ambient air <90% or respiratory rate > 30 resp/min) or diagnosis of acute respiratory distress syndrome according to criteria of the national institute of health and the colombian consensus (clinical findings, bilateral radiographic infiltrates, + oxygenation deficit as well: mild: 200 mmhg < pao2/fio2 (fraction of inspired oxygen) < 300 mm/hg; moderate: 100 mm/hg < pao2/fio2 < 200 mm/hg and, severe: pao2/fio2 < 100 mm/hg). - less than 14 days since the onset of symptoms. - hospitalized in a general internal medicine ward, special care unit, or those designated for managing patients with covid19.

inclusion criteria: - over 18 years old. - confirmed diagnosis of sars-cov-2 by polymerase chain reaction (pcr). - diagnosis of severe pneumonia according to criteria of the national institute of health and the colombian consensus (suspected respiratory infection, organ failure, arterial oxygen saturation (sao2) ambient air <90% or respiratory rate > 30 resp/min) or diagnosis of acute respiratory distress syndrome according to criteria of the national institute of health and the colombian consensus (clinical findings, bilateral radiographic infiltrates, + oxygenation deficit as well: mild: 200 mmhg < pao2/fio2 (fraction of inspired oxygen) < 300 mm/hg; moderate: 100 mm/hg < pao2/fio2 < 200 mm/hg and, severe: pao2/fio2 < 100 mm/hg). - less than 14 days since the onset of symptoms. - hospitalized in a general internal medicine ward, special care unit, or those designated for managing patients with covid19.