- pregnant or lactating women. - use of ivermectin in the two weeks before admission to the clinic - diseases affecting the blood-brain barrier (meningitis, encephalocranial trauma, acute subarachnoid hemorrhage) - limitation to understanding the explanations and giving consent, defined by the investigating physician. - patients with hiv/aids - that the patient is participating in another clinical trial.

- pregnant or lactating women. - use of ivermectin in the two weeks before admission to the clinic - diseases affecting the blood-brain barrier (meningitis, encephalocranial trauma, acute subarachnoid hemorrhage) - limitation to understanding the explanations and giving consent, defined by the investigating physician. - patients with hiv/aids - that the patient is participating in another clinical trial.