any vaccination/immunization performed within 30 days prior to inclusion in the study; therapy with steroids (with the exception of hormonal contraceptives and drugs used as hormone replacement therapy for menopause) and/or immunoglobulins or other blood products that did not end 30 days before inclusion in the study; therapy immunosuppressive drugs, which ended less than 3 months before inclusion in the study; subjects of the female gender during pregnancy or breastfeeding; postponed less than one year before inclusion in the study, acute coronary syndrome or stroke; tuberculosis, chronic systemic infections; burdened allergic history (the presence in the history of information about anaphylactic shock, quincke's edema, polymorphic exudative eczema, atopy, serum sickness), hypersensitivity or allergic reactions to the introduction of immunobiological drugs, known allergic reactions to the components of the drug, exacerbation of allergic diseases on the day of inclusion in the study; the presence of a history of neoplasms (icd codes c00-d09); donation of blood or plasma (450 ml or more) less than 2 months before inclusion in the study; splenectomy in history; neutropenia (decrease in the absolute number of neutrophils less than 1000/mm3), agranulocytosis, significant blood loss, severe anemia (hemoglobin less than 80 g/l), a history of immunodeficiency for 6 months before inclusion in the study; subjects with an active form of the disease caused by the human immunodeficiency virus, syphilis, hepatitis b and c; anorexia, protein deficiency of any origin; extensive tattoos at the sites of drug administration (deltoid muscle area), which do not allow to assess the local response to the introduction of ilp; alcoholism and drug addiction in history; consists on the account at the psychiatrist; subject's participation in any other interventional clinical trial within 90 days prior to the start of this study; any other condition of the research subject that, in the opinion of the research doctor, may prevent the completion of the study in accordance with the protocol; staff of research centers and other employees directly involved in the research (members of the research team) and their families. severe comorbid diseases that, in the opinion of the research doctor, may prevent participation in the study. -

any vaccination/immunization performed within 30 days prior to inclusion in the study; therapy with steroids (with the exception of hormonal contraceptives and drugs used as hormone replacement therapy for menopause) and/or immunoglobulins or other blood products that did not end 30 days before inclusion in the study; therapy immunosuppressive drugs, which ended less than 3 months before inclusion in the study; subjects of the female gender during pregnancy or breastfeeding; postponed less than one year before inclusion in the study, acute coronary syndrome or stroke; tuberculosis, chronic systemic infections; burdened allergic history (the presence in the history of information about anaphylactic shock, quincke's edema, polymorphic exudative eczema, atopy, serum sickness), hypersensitivity or allergic reactions to the introduction of immunobiological drugs, known allergic reactions to the components of the drug, exacerbation of allergic diseases on the day of inclusion in the study; the presence of a history of neoplasms (icd codes c00-d09); donation of blood or plasma (450 ml or more) less than 2 months before inclusion in the study; splenectomy in history; neutropenia (decrease in the absolute number of neutrophils less than 1000/mm3), agranulocytosis, significant blood loss, severe anemia (hemoglobin less than 80 g/l), a history of immunodeficiency for 6 months before inclusion in the study; subjects with an active form of the disease caused by the human immunodeficiency virus, syphilis, hepatitis b and c; anorexia, protein deficiency of any origin; extensive tattoos at the sites of drug administration (deltoid muscle area), which do not allow to assess the local response to the introduction of ilp; alcoholism and drug addiction in history; consists on the account at the psychiatrist; subject's participation in any other interventional clinical trial within 90 days prior to the start of this study; any other condition of the research subject that, in the opinion of the research doctor, may prevent the completion of the study in accordance with the protocol; staff of research centers and other employees directly involved in the research (members of the research team) and their families. severe comorbid diseases that, in the opinion of the research doctor, may prevent participation in the study. -

1. any vaccination/immunization performed within 30 days prior to inclusion in the study; 2. therapy with steroids (with the exception of hormonal contraceptives and drugs used as hormone replacement therapy for menopause) and/or immunoglobulins or other blood products that did not end 30 days before inclusion in the study; 3. therapy immunosuppressive drugs, which ended less than 3 months before inclusion in the study; 4. subjects of the female gender during pregnancy or breastfeeding; 5. postponed less than one year before inclusion in the study, acute coronary syndrome or stroke; 6. tuberculosis, chronic systemic infections; 7. burdened allergic history (the presence in the history of information about anaphylactic shock, quincke's edema, polymorphic exudative eczema, atopy, serum sickness), hypersensitivity or allergic reactions to the introduction of immunobiological drugs, known allergic reactions to the components of the drug, exacerbation of allergic diseases on the day of inclusion in the study; 8. the presence of a history of neoplasms (icd codes c00-d09); 9. donation of blood or plasma (450 ml or more) less than 2 months before inclusion in the study; 10. splenectomy in history; 11. neutropenia (decrease in the absolute number of neutrophils less than 1000/mm3), agranulocytosis, significant blood loss, severe anemia (hemoglobin less than 80 g/l), a history of immunodeficiency for 6 months before inclusion in the study; 12. subjects with an active form of the disease caused by the human immunodeficiency virus, syphilis, hepatitis b and c; 13. anorexia, protein deficiency of any origin; 14. extensive tattoos at the sites of drug administration (deltoid muscle area), which do not allow to assess the local response to the introduction of ilp; 15. alcoholism and drug addiction in history; 16. consists on the account at the psychiatrist; 17. subject's participation in any other interventional clinical trial within 90 days prior to the start of this study; 18. any other condition of the research subject that, in the opinion of the research doctor, may prevent the completion of the study in accordance with the protocol; 19. staff of research centers and other employees directly involved in the research (members of the research team) and their families. 20. severe comorbid diseases that, in the opinion of the research doctor, may prevent participation in the study. -

1. any vaccination/immunization performed within 30 days prior to inclusion in the study; 2. therapy with steroids (with the exception of hormonal contraceptives and drugs used as hormone replacement therapy for menopause) and/or immunoglobulins or other blood products that did not end 30 days before inclusion in the study; 3. therapy immunosuppressive drugs, which ended less than 3 months before inclusion in the study; 4. subjects of the female gender during pregnancy or breastfeeding; 5. postponed less than one year before inclusion in the study, acute coronary syndrome or stroke; 6. tuberculosis, chronic systemic infections; 7. burdened allergic history (the presence in the history of information about anaphylactic shock, quincke's edema, polymorphic exudative eczema, atopy, serum sickness), hypersensitivity or allergic reactions to the introduction of immunobiological drugs, known allergic reactions to the components of the drug, exacerbation of allergic diseases on the day of inclusion in the study; 8. the presence of a history of neoplasms (icd codes c00-d09); 9. donation of blood or plasma (450 ml or more) less than 2 months before inclusion in the study; 10. splenectomy in history; 11. neutropenia (decrease in the absolute number of neutrophils less than 1000/mm3), agranulocytosis, significant blood loss, severe anemia (hemoglobin less than 80 g/l), a history of immunodeficiency for 6 months before inclusion in the study; 12. subjects with an active form of the disease caused by the human immunodeficiency virus, syphilis, hepatitis b and c; 13. anorexia, protein deficiency of any origin; 14. extensive tattoos at the sites of drug administration (deltoid muscle area), which do not allow to assess the local response to the introduction of ilp; 15. alcoholism and drug addiction in history; 16. consists on the account at the psychiatrist; 17. subject's participation in any other interventional clinical trial within 90 days prior to the start of this study; 18. any other condition of the research subject that, in the opinion of the research doctor, may prevent the completion of the study in accordance with the protocol; 19. staff of research centers and other employees directly involved in the research (members of the research team) and their families. 20. severe comorbid diseases that, in the opinion of the research doctor, may prevent participation in the study. -