inclusion criteria: - subjects with voluntary signing of the informed consent form (icf), and capable of understanding and following the requirements. - healthy males or females aged ≥ 18 and < 65 years at the time of signing the icf. - body weight ≥ 50.0 kg and < 100.0 kg, and body mass index (bmi) ≥ 18.5 kg/m2 and < 30.0 kg/m2. - the subject is in good health as determined by the investigator according to medical history, physical examination, vital signs, 12-lead ecg, chest x-ray, and laboratory tests (hematology, serum chemistry, c-reactive protein, thyroid function, coagulation, etiology, urinalysis). - no plan of pregnancy and being willing to use continuous effective contraception for subjects (including partner) from informed consent to 6 months after administration of investigational product, see appendix 1 for the specific contraceptive measures.

inclusion criteria: - subjects with voluntary signing of the informed consent form (icf), and capable of understanding and following the requirements. - healthy males or females aged ≥ 18 and < 65 years at the time of signing the icf. - body weight ≥ 50.0 kg and < 100.0 kg, and body mass index (bmi) ≥ 18.5 kg/m2 and < 30.0 kg/m2. - the subject is in good health as determined by the investigator according to medical history, physical examination, vital signs, 12-lead ecg, chest x-ray, and laboratory tests (hematology, serum chemistry, c-reactive protein, thyroid function, coagulation, etiology, urinalysis). - no plan of pregnancy and being willing to use continuous effective contraception for subjects (including partner) from informed consent to 6 months after administration of investigational product, see appendix 1 for the specific contraceptive measures.