inclusion criteria: - adult - pcr confirmed covid-19 infection - symptoms developed more than 7 days - pao2/fio2 < 200 mmhg - positive pressure ventilation (non-invasive or invasive) or high flow nasal cannula (hfnc) higher than 45 l/min for less than 48 hours - requiring icu admission

inclusion criteria: - adult - pcr confirmed covid-19 infection - symptoms developed more than 7 days - pao2/fio2 < 200 mmhg - positive pressure ventilation (non-invasive or invasive) or high flow nasal cannula (hfnc) higher than 45 l/min for less than 48 hours - requiring icu admission