inclusion criteria: patient must be hospitalized, or had their inpatient stay extended, for covid-19. age >=18 years subject (or legally authorized representative) provides informed consent prior to initiation of any study procedures. subject (or legally authorized representative) understands and agrees to comply with planned study procedures. females of childbearing potential must agree to be abstinent or use a medical acceptable form of contraception from the time of enrollment through 30 days after last day of study drug laboratory confirmed sars-cov-2 rt-pcr test within 7 days of enrollment illness of any duration with spo2 of less than 94% on room air requiring supplemental oxygen via nasal canula or non-invasive mechanical ventilation, or mechanical ventilation or ecmo (5 to 7 on the 8-point scale)

inclusion criteria: patient must be hospitalized, or had their inpatient stay extended, for covid-19. age >=18 years subject (or legally authorized representative) provides informed consent prior to initiation of any study procedures. subject (or legally authorized representative) understands and agrees to comply with planned study procedures. females of childbearing potential must agree to be abstinent or use a medical acceptable form of contraception from the time of enrollment through 30 days after last day of study drug laboratory confirmed sars-cov-2 rt-pcr test within 7 days of enrollment illness of any duration with spo2 of less than 94% on room air requiring supplemental oxygen via nasal canula or non-invasive mechanical ventilation, or mechanical ventilation or ecmo (5 to 7 on the 8-point scale)

- inclusion criteria: 1. patient must be hospitalized, or had their inpatient stay extended, for covid-19. 2. age >=18 years 3. subject (or legally authorized representative) provides informed consent prior to initiation of any study procedures. 4. subject (or legally authorized representative) understands and agrees to comply with planned study procedures. 5. females of childbearing potential must agree to be abstinent or use a medical acceptable form of contraception from the time of enrollment through 30 days after last day of study drug 6. laboratory confirmed sars-cov-2 rt-pcr test within 7 days of enrollment 7. illness of any duration with spo2 of less than 94% on room air requiring supplemental oxygen via nasal canula or non-invasive mechanical ventilation, or mechanical ventilation or ecmo (5 to 7 on the 8-point scale)

- inclusion criteria: 1. patient must be hospitalized, or had their inpatient stay extended, for covid-19. 2. age >=18 years 3. subject (or legally authorized representative) provides informed consent prior to initiation of any study procedures. 4. subject (or legally authorized representative) understands and agrees to comply with planned study procedures. 5. females of childbearing potential must agree to be abstinent or use a medical acceptable form of contraception from the time of enrollment through 30 days after last day of study drug 6. laboratory confirmed sars-cov-2 rt-pcr test within 7 days of enrollment 7. illness of any duration with spo2 of less than 94% on room air requiring supplemental oxygen via nasal canula or non-invasive mechanical ventilation, or mechanical ventilation or ecmo (5 to 7 on the 8-point scale)