- known severe allergic reactions to monoclonal antibodies - active confirmed tuberculosis with ongoing treatment or obvious tuberculosis or obvious other bacterial, fungal or viral infection (besides covid-19) - in the opinion of the clinical team, progression to death is imminent and inevitable within the next 24 hours, irrespective of the provision of treatments - long-term oral anti-rejection or immunomodulatory drugs (including corticosteroids equivalent to methylprednison 15mg/day) - pregnant or lactating women. if needed, exclusion of pregnancy should be performed by laboratory test (u-hcg-o). - participating in other drug clinical trials - absolute neutrophil count < 1 x10e9/l - platelet count <50 x10e9/l - alat >10x uln

- known severe allergic reactions to monoclonal antibodies - active confirmed tuberculosis with ongoing treatment or obvious tuberculosis or obvious other bacterial, fungal or viral infection (besides covid-19) - in the opinion of the clinical team, progression to death is imminent and inevitable within the next 24 hours, irrespective of the provision of treatments - long-term oral anti-rejection or immunomodulatory drugs (including corticosteroids equivalent to methylprednison 15mg/day) - pregnant or lactating women. if needed, exclusion of pregnancy should be performed by laboratory test (u-hcg-o). - participating in other drug clinical trials - absolute neutrophil count < 1 x10e9/l - platelet count <50 x10e9/l - alat >10x uln