- pregnant or lactating women - severe comorbidity: severe heart disease, severe copd or o2-dependent copd, terminal cancer. - any confirmed or suspected immunosuppressive or immunodeficiency state, including hiv (regardless of treatment, cd4 count or viral load status); asplenia; severe recurrent infections and chronic use (more than 14 days) of immunosuppressive medication in the last 6 months, except for topical steroids or short-term oral steroids (cycle lasting ≤14 days); - history of anaphylaxis or severe allergic reaction; - previous use of any heterologous serum; - participation in trials of prophylactic drugs or vaccines for covid-19; - administration of immunoglobulins and / or any blood products in the previous three months.

- pregnant or lactating women - severe comorbidity: severe heart disease, severe copd or o2-dependent copd, terminal cancer. - any confirmed or suspected immunosuppressive or immunodeficiency state, including hiv (regardless of treatment, cd4 count or viral load status); asplenia; severe recurrent infections and chronic use (more than 14 days) of immunosuppressive medication in the last 6 months, except for topical steroids or short-term oral steroids (cycle lasting ≤14 days); - history of anaphylaxis or severe allergic reaction; - previous use of any heterologous serum; - participation in trials of prophylactic drugs or vaccines for covid-19; - administration of immunoglobulins and / or any blood products in the previous three months.