- has a known hypersensitivity to any component of v590 or placebo. - has any known or suspected active clinically significant autoimmune disease or immunosuppressive condition, acquired or congenital, as determined by medical history and/or physical examination. - has thrombocytopenia or other coagulation disorder contraindicating intramuscular vaccination or repeated venipuncture. - has history or current evidence of any condition, therapy, laboratory abnormality, or other circumstance that might expose the participant to risk by participating in the study, confound the results of the study or interfere with the participant's participation for the full duration of the study. - has a history of ongoing liver disease or, at the time of screening, has any one of the following: alanine aminotransferase (alt) or aspartate aminotransferase (ast) > 1.5 × upper limit of normal (uln), alkaline phosphatase and direct bilirubin > uln (total bilirubin may be up to 2 × uln as long as direct bilirubin is equal to or below the uln), or prothrombin time (pt) international normalized ratio (inr) > 1.25. - has a history of asthma or allergic asthma that required systemic corticosteroids in the previous year. - has a history of guillain-barré syndrome. - has a history of diabetes mellitus, requiring medication at the time of assessment, or has a hemoglobin a1c ≥ 6.5. - has a history of any medical condition that would put the participant at risk for severe sars-cov-2 disease as judged by the investigator. - has any ongoing, symptomatic, acute or chronic illness requiring medical or surgical care or any condition that is immunosuppressive. - is mentally or legally incapacitated, has significant emotional problems at the time of screening visit or expected during the conduct of the study or has a history of clinically significant psychiatric disorder of the last 5 years. - has a history of cancer (malignancy). - participant has an estimated glomerular filtration rate (egfr) ≤60 ml/min/1.73 m^2. - has a history of significant multiple and/or severe allergies or has had an anaphylactic reaction or significant intolerability to a vaccine or prescription or non prescription drugs or food as judged by the investigator. - is positive for hepatitis b surface antigen, hepatitis c antibodies or human immunodeficiency virus (hiv)-1 or 2 antibodies. individuals with antibodies to hepatitis c may be enrolled if hepatitis c viral load is negative and there is no evidence of or history of liver disease. - had major surgery, donated or lost 1 unit of blood (approximately 500 ml) within 4 weeks prior to the pre-study (screening) visit. - a wocbp who has a positive urine or serum pregnancy test before vaccination. - a wocbp who is breastfeeding. - has any unstable chronic medical condition, including one that has resulted in change in therapy (medication or other) in the 30 days prior to randomization or hospitalization in the previous year or might be predicted to result in hospitalization in the year after enrollment. - has received or is expected to receive any sars-cov-2 vaccine or other coronavirus vaccine during the study (except v590), is using investigational agents for prophylaxis of sars-cov-2 or is taking any systemic antiviral medications. - has received any intra-articular steroid injections within the 3 months prior to study vaccination or is expected to require intra-articular steroid injection during the study. - is receiving immunosuppressive therapy or has received immunosuppressive therapy within 6 months of enrollment. - has received a blood transfusion or blood products, including immunoglobulin, in the 3 months before anticipated study vaccination. - is expected to be receiving or is currently receiving antipyretic or analgesic medication on a daily or every other day basis from randomization through day 7 - has ever participated in an investigational study of a sars-cov-2 vaccine, a coronavirus vaccine, or an antiviral or other biologic product intended for the treatment of covid-19. - has participated in another vaccine study within 3 months prior to screening or has participated in an investigational study within 4 weeks prior to the (screening) visit. - has ever received a vaccine based on vesicular stomatitis virus (vsv). - has a fridericia's corrected time from q wave to t wave (qtcf) interval >470 msec (male) or >480 msec (female), has a history of risk factors for torsades de pointes, or has uncorrected hypokalemia or hypomagnesemia. - is under the age of legal consent. - is smoking or vaping and/or has a history of chronic smoking or vaping within approximately six months prior to planned vaccination. - does not agree to follow the alcohol restrictions - has a tattoo, scar, or other physical finding at the area of the vaccination site that would interfere with intramuscular injection or a local tolerability assessment. - is a regular user of any illicit drugs or has a history of drug (including alcohol) abuse within approximately 1 year. - presents any concern by the investigator regarding safe participation in the study or for any other reason the investigator considers the participant inappropriate for participation in the study. - lives in a nursing home or long-term care facility. - is currently working in an occupation with high risk of exposure to sars-cov-2 (e.g., health care worker with direct patient contact, emergency response personnel).

- has a known hypersensitivity to any component of v590 or placebo. - has any known or suspected active clinically significant autoimmune disease or immunosuppressive condition, acquired or congenital, as determined by medical history and/or physical examination. - has thrombocytopenia or other coagulation disorder contraindicating intramuscular vaccination or repeated venipuncture. - has history or current evidence of any condition, therapy, laboratory abnormality, or other circumstance that might expose the participant to risk by participating in the study, confound the results of the study or interfere with the participant's participation for the full duration of the study. - has a history of ongoing liver disease or, at the time of screening, has any one of the following: alanine aminotransferase (alt) or aspartate aminotransferase (ast) > 1.5 × upper limit of normal (uln), alkaline phosphatase and direct bilirubin > uln (total bilirubin may be up to 2 × uln as long as direct bilirubin is equal to or below the uln), or prothrombin time (pt) international normalized ratio (inr) > 1.25. - has a history of asthma or allergic asthma that required systemic corticosteroids in the previous year. - has a history of guillain-barré syndrome. - has a history of diabetes mellitus, requiring medication at the time of assessment, or has a hemoglobin a1c ≥ 6.5. - has a history of any medical condition that would put the participant at risk for severe sars-cov-2 disease as judged by the investigator. - has any ongoing, symptomatic, acute or chronic illness requiring medical or surgical care or any condition that is immunosuppressive. - is mentally or legally incapacitated, has significant emotional problems at the time of screening visit or expected during the conduct of the study or has a history of clinically significant psychiatric disorder of the last 5 years. - has a history of cancer (malignancy). - participant has an estimated glomerular filtration rate (egfr) ≤60 ml/min/1.73 m^2. - has a history of significant multiple and/or severe allergies or has had an anaphylactic reaction or significant intolerability to a vaccine or prescription or non prescription drugs or food as judged by the investigator. - is positive for hepatitis b surface antigen, hepatitis c antibodies or human immunodeficiency virus (hiv)-1 or 2 antibodies. individuals with antibodies to hepatitis c may be enrolled if hepatitis c viral load is negative and there is no evidence of or history of liver disease. - had major surgery, donated or lost 1 unit of blood (approximately 500 ml) within 4 weeks prior to the pre-study (screening) visit. - a wocbp who has a positive urine or serum pregnancy test before vaccination. - a wocbp who is breastfeeding. - has any unstable chronic medical condition, including one that has resulted in change in therapy (medication or other) in the 30 days prior to randomization or hospitalization in the previous year or might be predicted to result in hospitalization in the year after enrollment. - has received or is expected to receive any sars-cov-2 vaccine or other coronavirus vaccine during the study (except v590), is using investigational agents for prophylaxis of sars-cov-2 or is taking any systemic antiviral medications. - has received any intra-articular steroid injections within the 3 months prior to study vaccination or is expected to require intra-articular steroid injection during the study. - is receiving immunosuppressive therapy or has received immunosuppressive therapy within 6 months of enrollment. - has received a blood transfusion or blood products, including immunoglobulin, in the 3 months before anticipated study vaccination. - is expected to be receiving or is currently receiving antipyretic or analgesic medication on a daily or every other day basis from randomization through day 7 - has ever participated in an investigational study of a sars-cov-2 vaccine, a coronavirus vaccine, or an antiviral or other biologic product intended for the treatment of covid-19. - has participated in another vaccine study within 3 months prior to screening or has participated in an investigational study within 4 weeks prior to the (screening) visit. - has ever received a vaccine based on vesicular stomatitis virus (vsv). - has a fridericia's corrected time from q wave to t wave (qtcf) interval >470 msec (male) or >480 msec (female), has a history of risk factors for torsades de pointes, or has uncorrected hypokalemia or hypomagnesemia. - is under the age of legal consent. - is smoking or vaping and/or has a history of chronic smoking or vaping within approximately six months prior to planned vaccination. - does not agree to follow the alcohol restrictions - has a tattoo, scar, or other physical finding at the area of the vaccination site that would interfere with intramuscular injection or a local tolerability assessment. - is a regular user of any illicit drugs or has a history of drug (including alcohol) abuse within approximately 1 year. - presents any concern by the investigator regarding safe participation in the study or for any other reason the investigator considers the participant inappropriate for participation in the study. - lives in a nursing home or long-term care facility. - is currently working in an occupation with high risk of exposure to sars-cov-2 (e.g., health care worker with direct patient contact, emergency response personnel).