inclusion criteria: - patients with moderate to severe ards per berlin criteria secondary to covid-19. moderate to severe is defined in appendix as the following: moderate partial pressure of arterial oxygen (pao2)/fio2 of 100-200 mm hg, severe pao2/fio2 of less than 100 mm hg - negative pregnancy test in a woman with childbearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization - patient or legally authorized representative consent - because of the nature of covid-19, patients enrolled on this study with covid-19 associated ards may have been previously enrolled in other investigational new drug (ind) trials for their cancer diagnosis or covid-19. these enrollments will not exclude them from enrollment to this study

inclusion criteria: - patients with moderate to severe ards per berlin criteria secondary to covid-19. moderate to severe is defined in appendix as the following: moderate partial pressure of arterial oxygen (pao2)/fio2 of 100-200 mm hg, severe pao2/fio2 of less than 100 mm hg - negative pregnancy test in a woman with childbearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization - patient or legally authorized representative consent - because of the nature of covid-19, patients enrolled on this study with covid-19 associated ards may have been previously enrolled in other investigational new drug (ind) trials for their cancer diagnosis or covid-19. these enrollments will not exclude them from enrollment to this study

inclusion criteria: - patients with moderate to severe ards per berlin criteria secondary to covid-19. moderate to severe is defined in appendix as the following: moderate partial pressure of arterial oxygen (pao2)/fio2 of 100-200 mm hg, severe pao2/fio2 of less than 100 mm hg - negative pregnancy test in a woman with childbearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization - patient or legally authorized representative consent

inclusion criteria: - patients with moderate to severe ards per berlin criteria secondary to covid-19. moderate to severe is defined in appendix as the following: moderate partial pressure of arterial oxygen (pao2)/fio2 of 100-200 mm hg, severe pao2/fio2 of less than 100 mm hg - negative pregnancy test in a woman with childbearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization - patient or legally authorized representative consent