subject is currently participating in another clinical investigation pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period presence of comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results have child-pugh class c cirrhosis have platelet count <30.000/ul contraindications for heparin sodium for injection subjects demonstrating any contraindication for this treatment as described in the ifu subjects with known allergy of polyethylene and copolyester subjects with hospital-acquired sars-cov-2 infections subject is held in an institution by court or official order subject is dependent on the sponsor or investigator so that consent can no longer be considered voluntary

subject is currently participating in another clinical investigation pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period presence of comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results have child-pugh class c cirrhosis have platelet count <30.000/ul contraindications for heparin sodium for injection subjects demonstrating any contraindication for this treatment as described in the ifu subjects with known allergy of polyethylene and copolyester subjects with hospital-acquired sars-cov-2 infections subject is held in an institution by court or official order subject is dependent on the sponsor or investigator so that consent can no longer be considered voluntary

subject is currently participating in another clinical investigation pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period presence of comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results have neutropenia (absolute neutrophil count <500 cells/ul) have child-pugh class c cirrhosis have platelet count <30.000/ul contraindications for heparin sodium for injection subjects demonstrating any contraindication for this treatment as described in the ifu subjects with known allergy of polyethylene and copolyester subjects with hospital-acquired sars-cov-2 infections subject is held in an institution by court or official order subject is dependent on the sponsor or investigator so that consent can no longer be considered voluntary

subject is currently participating in another clinical investigation pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period presence of comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results have neutropenia (absolute neutrophil count <500 cells/ul) have child-pugh class c cirrhosis have platelet count <30.000/ul contraindications for heparin sodium for injection subjects demonstrating any contraindication for this treatment as described in the ifu subjects with known allergy of polyethylene and copolyester subjects with hospital-acquired sars-cov-2 infections subject is held in an institution by court or official order subject is dependent on the sponsor or investigator so that consent can no longer be considered voluntary

1. subject is currently participating in another clinical investigation 2. pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period 3. presence of comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results 4. have neutropenia (absolute neutrophil count <500 cells/ul) 5. have child-pugh class c cirrhosis 6. have platelet count <30.000/ul 7. contraindications for heparin sodium for injection 8. subjects demonstrating any contraindication for this treatment as described in the ifu 9. subjects with known allergy of polyethylene and copolyester 10. subjects with hospital-acquired sars-cov-2 infections 11. subject is held in an institution by court or official order 12. subject is dependent on the sponsor or investigator so that consent can no longer be considered voluntary

1. subject is currently participating in another clinical investigation 2. pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period 3. presence of comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results 4. have neutropenia (absolute neutrophil count <500 cells/ul) 5. have child-pugh class c cirrhosis 6. have platelet count <30.000/ul 7. contraindications for heparin sodium for injection 8. subjects demonstrating any contraindication for this treatment as described in the ifu 9. subjects with known allergy of polyethylene and copolyester 10. subjects with hospital-acquired sars-cov-2 infections 11. subject is held in an institution by court or official order 12. subject is dependent on the sponsor or investigator so that consent can no longer be considered voluntary

1. subject is currently participating in another clinical investigation 2. pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period 3. presence of comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results 4. have neutropenia (absolute neutrophil count <500 cells/ul) 5. have child-pugh class c cirrhosis 6. have platelet count <30.000/ul 7. contraindications for heparin sodium for injection 8. subjects demonstrating any contraindication for this treatment as described in the ifu

1. subject is currently participating in another clinical investigation 2. pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period 3. presence of comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements, or impact the scientific soundness of the clinical investigation results 4. have neutropenia (absolute neutrophil count <500 cells/ul) 5. have child-pugh class c cirrhosis 6. have platelet count <30.000/ul 7. contraindications for heparin sodium for injection 8. subjects demonstrating any contraindication for this treatment as described in the ifu