- currently hospitalized or judged by the investigator as likely to require hospitalization in the next 24 hours - symptoms consistent with severe covid-19 - participants who, in the judgement of the investigator are likely to die in the next 7 days - severely immunocompromised participants

- currently hospitalized or judged by the investigator as likely to require hospitalization in the next 24 hours - symptoms consistent with severe covid-19 - participants who, in the judgement of the investigator are likely to die in the next 7 days - severely immunocompromised participants