- mental inability, reluctance or language difficulties that result in difficulty understanding the meaning of study participation - known or suspected allergy against pulmozyme - chronic obstructive pulmonary disease stage iii-iv or another comparable chronic respiratory disease - participation in a clinical study with an investigational product during the last 30 days - previous participation in this study - pregnancy. women of childbearing potential must agree to use contraceptives for the duration of the study period - any condition that, in the opinion of the investigator, would place the patient at increased risk or preclude the patient's compliance with the study

- mental inability, reluctance or language difficulties that result in difficulty understanding the meaning of study participation - known or suspected allergy against pulmozyme - chronic obstructive pulmonary disease stage iii-iv or another comparable chronic respiratory disease - participation in a clinical study with an investigational product during the last 30 days - previous participation in this study - pregnancy. women of childbearing potential must agree to use contraceptives for the duration of the study period - any condition that, in the opinion of the investigator, would place the patient at increased risk or preclude the patient's compliance with the study