inclusion criteria: - patient older than 18 years of age - covid19 diagnosis: - rt pcr for covid-19 positive in respiratory tract sample (nasopharyngeal swab, sputum, bronchoalveolar lavage) - at least 2 of the following symptoms: cough, odynophagia, dyspnea, asthenia, adynamia, gastrointestinal symptoms. - findings compatible with viral pneumonia on chest tomography or chest radiography. - risk of respiratory deterioration given by at least 1 of the following: - hypoxemia: pao2 <60 mmhg, sao2 <90% or supplemental o2 requirement to maintain sao2> 90% - call score ≥ 9 points - fr> 30 / min - pao2 / fio2 less than 200 - intubated patients without deterioration of other organs (without acute kidney injury, without elevated transaminases). - progression of radiological findings of pneumonia. - patients with moderate or severe oxygenation disorder, with diaphragm of 200-100 and <100 respectively, who require supplemental oxygen at high flow (non-rebreathing mask or high flow cannula). - complete record of medical history, allergies, and medical conditions that preclude the use of prostaglandin e1 analogs have been ruled out. - voluntary participation in the study, demonstrating fullness through informed consent.

inclusion criteria: - patient older than 18 years of age - covid19 diagnosis: - rt pcr for covid-19 positive in respiratory tract sample (nasopharyngeal swab, sputum, bronchoalveolar lavage) - at least 2 of the following symptoms: cough, odynophagia, dyspnea, asthenia, adynamia, gastrointestinal symptoms. - findings compatible with viral pneumonia on chest tomography or chest radiography. - risk of respiratory deterioration given by at least 1 of the following: - hypoxemia: pao2 <60 mmhg, sao2 <90% or supplemental o2 requirement to maintain sao2> 90% - call score ≥ 9 points - fr> 30 / min - pao2 / fio2 less than 200 - intubated patients without deterioration of other organs (without acute kidney injury, without elevated transaminases). - progression of radiological findings of pneumonia. - patients with moderate or severe oxygenation disorder, with diaphragm of 200-100 and <100 respectively, who require supplemental oxygen at high flow (non-rebreathing mask or high flow cannula). - complete record of medical history, allergies, and medical conditions that preclude the use of prostaglandin e1 analogs have been ruled out. - voluntary participation in the study, demonstrating fullness through informed consent.