inclusion criteria: - patients ≥ 18 years, with confirmed laboratory covid-19, and have one or more of the following 4 conditions: - 1. respiratory frequency ≥ 30/min, - 2. blood oxygen saturation ≤ 93% on room air, - 3. partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300 mmhg, - 4. pulmonary infiltrates occupying more than 50% of both lungs. exclusion criteria - any patient with prior allergic history to plasma or - allergy to plasma products or - septic shock or - multiple organ failure.

inclusion criteria: - patients ≥ 18 years, with confirmed laboratory covid-19, and have one or more of the following 4 conditions: - 1. respiratory frequency ≥ 30/min, - 2. blood oxygen saturation ≤ 93% on room air, - 3. partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300 mmhg, - 4. pulmonary infiltrates occupying more than 50% of both lungs. exclusion criteria - any patient with prior allergic history to plasma or - allergy to plasma products or - septic shock or - multiple organ failure.