inclusion criteria: positive sars-cov-2 diagnostic (on pharyngeal swab of deep airways material) positive pressure ventilation (either non-invasive or invasive) from > 24 hours invasive mechanical ventilation from < 96 hours p/f ratio < 150 d-dimer level > 6 x upper limit of local reference range pcr > 6 fold upper limit of local reference range

inclusion criteria: positive sars-cov-2 diagnostic (on pharyngeal swab of deep airways material) positive pressure ventilation (either non-invasive or invasive) from > 24 hours invasive mechanical ventilation from < 96 hours p/f ratio < 150 d-dimer level > 6 x upper limit of local reference range pcr > 6 fold upper limit of local reference range

inclusion criteria: 1. positive sars-cov-2 diagnostic (on pharyngeal swab of deep airways material) 2. positive pressure ventilation (either non-invasive or invasive) from > 24 hours 3. invasive mechanical ventilation from < 96 hours 4. p/f ratio < 150 5. d-dimer level > 6 x upper limit of local reference range 6. pcr > 6 fold upper limit of local reference range

inclusion criteria: 1. positive sars-cov-2 diagnostic (on pharyngeal swab of deep airways material) 2. positive pressure ventilation (either non-invasive or invasive) from > 24 hours 3. invasive mechanical ventilation from < 96 hours 4. p/f ratio < 150 5. d-dimer level > 6 x upper limit of local reference range 6. pcr > 6 fold upper limit of local reference range